Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases

被引：12

作者：

Smoldovskaya, Olga ^{[1
]}

Feyzkhanova, Guzel ^{[1
]}

Voloshin, Sergei ^{[1
]}

Arefieva, Alla ^{[1
]}

Chubarova, Antonina ^{[2
]}

Pavlushkina, Ludmila ^{[2
]}

Filatova, Tatiana ^{[2
]}

Antonova, Eugenia ^{[2
]}

Timofeeva, Elena ^{[2
]}

Butvilovskaya, Veronika ^{[1
]}

Lysov, Yuri ^{[1
]}

Zasedatelev, Alexander ^{[1
]}

Rubina, Alla ^{[1
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Vavilova Str 32, Moscow 119991, Russia

[2] Filatov Moscow City, Pediat Clin 13, Moscow, Russia

来源：

WORLD ALLERGY ORGANIZATION JOURNAL | 2018年 / 11卷

基金：

俄罗斯科学基金会;

关键词：

Allergy diagnostics; IgE; IgG4; Microarrays; Sensitization; Asthma; Dermatitis; Rhinitis; EARLY-CHILDHOOD; FOOD ALLERGY; SENSITIZATION; ANTIBODIES; ASTHMA; IMMUNOTHERAPY; DIAGNOSTICS; TOLERANCE; MOLECULES; RHINITIS;

D O I：

10.1186/s40413-018-0220-5

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BackgroundIn additionto allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and sIgG4 patterns in the most common allergic disorders: bronchial asthma, upper airway disorders and atopic dermatitis.MethodsIn this study a screening analysis of blood serum samples from 673 patients aged from 6months to 17years with different allergic entities was performed on microarrays. sIgE and sIgG4 levels to the most common allergens were estimated.ResultssIgE response to most pollen allergens is more strongly associated with respiratory diseases than with atopic dermatitis, while sIgE responses to cat and dog dander are more strongly associated with bronchial asthma than with atopic dermatitis and upper airway disorders such as rhinosinusitis and allergic rhinitis. A lower prevalence of sIgG4 to pollen allergens in cases of atopic dermatitis is observed compared with that in cases of asthma and upper airway disorders. Analyzing all the allergic disorders, one can see that sIgG4 response to inhalant allergens is strongly associated with sensitization to the corresponding allergen.ConclusionAllergen-specific IgE and IgG4 patterns that are relevant to concrete allergic diseases differ by sIgE and sIgG4 prevalences to defined allergens.

引用

页数：10

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