Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637 -: I.: Production, isolation and biological properties

被引：26
作者：
Tomoda, H
Tabata, N
Masuma, R
Si, SY
Omura, S [1 ]
机构：
[1] Kitasato Inst, Biol Funct Res Ctr, Minato Ku, Tokyo 108, Japan
[2] Kitasato Univ, Grad Sch Pharmaceut Sci, Minato Ku, Tokyo 108, Japan
来源：
JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 07期
关键词：
D O I：
10.7164/antibiotics.51.618
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Penicillium SP. FO-5637, a soil isolate, was found to produce a series of inhibitors of cholesteryl ester transfer protein (CETP). Novel active compounds, designated erabulenols A and B, were isolated from the fermentation broth of the producing strain by solvent extraction, ODS column chromatography and HPLC. Erabulenols A and B inhibit human CETP activity with IC50 values of 47.7 and 55.2 mu M in an in vitro assay system containing 200 mu M BSA, respectively.
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页码：618 / 623
页数：6
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