Association of haplotypes of interleukin-10 gene with the risk of cancer

被引：6

作者：

Pogoda, T. V. ^{[1
]}

Marsheva, O. V. ^{[1
]}

Kostin, P. A. ^{[1
]}

Maksimov, V. N. ^{[2
]}

Kulikov, I. V. ^{[2
]}

Openko, T. G. ^{[2
]}

Simonova, G. I. ^{[2
]}

Voyevoda, M. I. ^{[2
]}

Generozov, E. V. ^{[1
]}

Govorun, V. M. ^{[1
]}

机构：

[1] Fed Agcy Hlth Care & Social Dev, Inst Physicochem Med, Moscow, Russia

[2] Russian Acad Med Sci, Inst Therapy, Siberian Div, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 144卷 / 03期

关键词：

haplotypes; interleukin-10; genetic predisposition; cancer;

D O I：

10.1007/s10517-007-0339-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Polymorphisms of promotor region of IL-8, IL-10, and IL-12 genes were analyzed in cancer patients and subjects without history of cancer. The distribution of alleles of the analyzed polymorphisms in the control group coincided with that in other Caucasian populations. The incidences of three IL-10 gene polymorphisms (G-1082A, C-819T, and C-592A) significantly differed in controls and patients. Of 8 theoretically probable IL-10 gene haplotypes determined by these polymorphisms, 3 variants were revealed. Haplotype ACC was more incident in cancer patients, while ATA haplotype was rarer. The results are in line with the findings of other studies indicating the involvement of the immune system genes in the pathogenesis of cancer.

引用

页码：385 / 389

页数：5

共 15 条

[1] Influence of interleukin-10 genetic polymorphism on survival rates in melanoma patients with advanced disease [J].

Alonso, R ;

Suarez, A ;

Castro, P ;

Lacave, AJ ;

Gutierrez, C .

MELANOMA RESEARCH, 2005, 15 (01) :53-60

[2] Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation [J].

Gordon, MA ;

Gil, J ;

Lu, B ;

Zhang, W ;

Yang, DY ;

Yun, J ;

Schneider, S ;

Groshen, S ;

Iqbal, S ;

Press, OA ;

Rhodes, K ;

Lenz, HJ .

PHARMACOGENOMICS, 2006, 7 (01) :67-88

[3] An interleukin-10 promoter polymorphism may influence tumor development in renal cell carcinoma [J].

Havranek, E ;

Howell, WM ;

Fussell, HM ;

Whelan, JA ;

Whelan, MA ;

Pandha, HS .

JOURNAL OF UROLOGY, 2005, 173 (03) :709-712

[4]

Kadagidze ZG, 2003, PRAKT ONKOL, V4, P131

[5] Interleukin-10 gene promoter polymorphism in English and Polish healthy controls.: Polymerase chain reaction haplotyping using 3′ mismatches in forward and reverse primers [J].

Koss, K ;

Fanning, GC ;

Welsh, KI ;

Jewell, DP .

GENES AND IMMUNITY, 2000, 1 (05) :321-324

[6] Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk [J].

Langsenlehner, U ;

Krippl, P ;

Renner, W ;

Yazdani-Biuki, B ;

Eder, T ;

Köppel, H ;

Wascher, TC ;

Paulweber, B ;

Samonigg, H .

BREAST CANCER RESEARCH AND TREATMENT, 2005, 90 (02) :113-115

[7] CANCER-FAMILY SYNDROME - PRAGMATIC BASIS FOR SYNDROME IDENTIFICATION [J].

LYNCH, HT ;

LYNCH, PM .

DISEASES OF THE COLON & RECTUM, 1979, 22 (02) :106-110

[8] The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland [J].

Macarthur, M ;

Sharp, L ;

Hold, GL ;

Little, J ;

El-Omar, EM .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (07) :1613-1618

[9]

PONDER BA, 2001, NATURE, V411, P6835

[10] IL-12: a promising adjuvant for cancer vaccination [J].

Portielje, JEA ;

Gratama, JW ;

van Ojik, HH ;

Stoter, G ;

Kruit, WHJ .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2003, 52 (03) :133-144

← 1 2 →