Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report

被引：2

作者：

Santana, Marcela Araujo de Oliveira ^{[1
]}

da Costa, Willian Vargas Tenorio ^{[2
]}

Celestino, Isadora Costa ^{[3
]}

dos Santos, Diogo Fernandes ^{[1
,2
]}

Dornelas, Bruno de Carvalho ^{[3
,4
]}

Pavelka, Matthew Martin ^{[5
]}

Luppi, Andrea De Martino ^{[1
,3
]}

Goulart, Isabela Maria Bernardes ^{[1
,2
]}

机构：

[1] Univ Fed Uberlandia, Clin Hosp, Fac Med, Natl Reference Ctr Sanit Dermatol & Leprosy, Uberlandia, Brazil

[2] Univ Fed Uberlandia, Fac Med, Uberlandia, Brazil

[3] Univ Fed Uberlandia, Fac Med, Postgrad Program Hlth Sci, Uberlandia, Brazil

[4] Univ Fed Uberlandia, Clin Hosp, Fac Med, Pathol Dept, Uberlandia, Brazil

[5] Indiana Univ, Sch Med, Terre Haute, IN USA

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

lepromatous leprosy; bone marrow; neuropathy; fever of unknown origin; case report; NECROSIS-FACTOR-ALPHA; RELAPSE; LIVER; GENE;

D O I：

10.3389/fimmu.2022.916319

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium leprae, the etiologic agent of leprosy, is an acid-fast-staining and slow-growing bacilli that infect macrophages and Schwann cells individually or through forming globi. The clinical presentation of leprosy is broad and depends on the host immune response. We report a case of a 42-year-old Brazilian man presenting with fever of unknown origin (FUO), anemia, wasting syndrome, and neuropathy. The diagnosis of lepromatous leprosy was made after an extensive investigation revealed the presence of M. leprae in the bone marrow. Bone marrow involvement in leprosy is rare and some authors believe the presence of M. leprae in the bone marrow can act as a reservoir of the disease facilitating future relapses. It is important to investigate bone marrow involvement in leprosy, especially when the patient presents with cytopenias and positive epidemiologic history.

引用

页数：6

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