Cytosolic Proteostasis Networks of the Nlitochondrial Stress Response

被引:88
作者
D'Amico, Davide [1 ]
Sorrentino, Vincenzo [1 ]
Auwerx, Johan [1 ]
机构
[1] Ecole Polytech Fed Lausanne, Lab Integrat & Syst Physiol, Lausanne, Switzerland
基金
瑞士国家科学基金会; 美国国家卫生研究院;
关键词
UNFOLDED PROTEIN RESPONSE; MITOCHONDRIAL COMPLEX-I; OXIDATIVE STRESS; TRANSLATION INITIATION; PROTEASOME ACTIVITY; MTOR INHIBITION; ACTIVATION; UBIQUITIN; PARKIN; PHOSPHORYLATION;
D O I
10.1016/j.tibs.2017.05.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondrial stress requires timely intervention to prevent mitochondria' and cellular dysfunction. Re-establishing the correct protein homeostasis is crucial for coping with mitochondria' stress and maintaining cellular homeostasis. The best-characterized adaptive pathways for mitochondria' stress involve a signal originating from stressed mitochondria that triggers a nuclear response. However, recent findings have shown that mitochondria' stress also affects a complex network of protein homeostasis pathways in the cytosol. We review how mitochondria' dysregulation affects cytosolic proteostasis by regulating the quantity and quality of protein synthesis, protein stability, and protein degradation, leading to an integrated regulation of cellular metabolism and proliferation. This mitochondria to cytosol network extends the current model of the mitochondria' stress response, with potential applications in the treatment of mitochondria' disease.
引用
收藏
页码:712 / 725
页数:14
相关论文
共 97 条
[1]   Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease [J].
Anckar, Julius ;
Sistonen, Lea .
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80, 2011, 80 :1089-1115
[2]   Pharmacological approaches to restore mitochondrial function [J].
Andreux, Penelope A. ;
Houtkooper, Riekelt H. ;
Auwerx, Johan .
NATURE REVIEWS DRUG DISCOVERY, 2013, 12 (06) :465-483
[3]   Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications [J].
Apostolova, Nadezda ;
Victor, Victor M. .
ANTIOXIDANTS & REDOX SIGNALING, 2015, 22 (08) :686-729
[4]   The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression [J].
B'chir, Wafa ;
Maurin, Anne-Catherine ;
Carraro, Valerie ;
Averous, Julien ;
Jousse, Celine ;
Muranishi, Yuki ;
Parry, Laurent ;
Stepien, Georges ;
Fafournoux, Pierre ;
Bruhat, Alain .
NUCLEIC ACIDS RESEARCH, 2013, 41 (16) :7683-7699
[5]   Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2 [J].
Baker, Brooke M. ;
Nargund, Amrita M. ;
Sun, Tiffany ;
Haynes, Cole M. .
PLOS GENETICS, 2012, 8 (06)
[6]   Mitochondrial dysfunction remodels one - carbon metabolism in human cells [J].
Bao, Xiaoyan Robert ;
Ong, Shao-En ;
Goldberger, Olga ;
Peng, Jun ;
Sharma, Rohit ;
Thompson, Dawn A. ;
Vafai, Scott B. ;
Cox, Andrew G. ;
Marutani, Eizo ;
Ichinose, Fumito ;
Goessling, Wolfram ;
Regev, Aviv ;
Carr, Steven A. ;
Clish, Clary B. ;
Mootha, Vamsi K. .
ELIFE, 2016, 5
[7]  
Barbour Jayne Alexandra, 2014, Int J Cell Biol, V2014, P156020, DOI 10.1155/2014/156020
[8]   The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy [J].
Bingol, Baris ;
Tea, Joy S. ;
Phu, Lilian ;
Reichelt, Mike ;
Bakalarski, Corey E. ;
Song, Qinghua ;
Foreman, Oded ;
Kirkpatrick, Donald S. ;
Sheng, Morgan .
NATURE, 2014, 510 (7505) :370-+
[9]   Tetracyclines cause cell stress-dependent ATF4 activation and mTOR inhibition [J].
Bruning, Ansgar ;
Brem, German J. ;
Vogel, Marianne ;
Mylonas, Ioannis .
EXPERIMENTAL CELL RESEARCH, 2014, 320 (02) :281-289
[10]   Activation of mTOR: a culprit of Alzheimer's disease? [J].
Cai, Zhiyou ;
Chen, Guanghui ;
He, Wenbo ;
Xiao, Ming ;
Yan, Liang-Jun .
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2015, 11 :1015-1030