Absence of adverse effects following the gavage administration of methyl propyl trisulfide to Sprague-Dawley rats for 90 days

被引：4

作者：

Bastaki, Maria ^{[1
]}

Aubanel, Michel ^{[2
]}

Cachet, Thierry ^{[3
]}

Demyttenaere, Jan ^{[4
]}

Diop, Maodo Malick ^{[5
]}

Harman, Christie L. ^{[6
]}

Hayashi, Shim-mo ^{[7
]}

Koetzner, Lee ^{[8
]}

Krammer, Gerhard ^{[9
]}

Li, Xiaodong ^{[10
]}

Llewellyn, Craig ^{[11
]}

Mendes, Odete ^{[8
]}

Renskers, Kevin J. ^{[12
]}

Schnabel, Jurgen ^{[13
]}

Smith, Benjamin P. C. ^{[14
]}

Taylor, Sean V. ^{[1
]}

机构：

[1] Int Org Flavor Ind, 1101 17th St NW,Suite 700, Washington, DC 20036 USA

[2] Kerry Flavours France, Z1 Plan BP 82067,51 Ave Jean Mauberl, F-06131 Grasse, France

[3] Int Org Flavor Ind, Ave Arts 6, B-1210 Brussels, Belgium

[4] European Flavour Assoc, Ave Arts 6, B-1210 Brussels, Belgium

[5] V Mane Fils, 620 Route Grasse, F-06620 Le Bar Sur Loup, France

[6] Flavor & Extract Manufacturers Assoc, 1101 17th St NW,Suite 700, Washington, DC 20036 USA

[7] Japan Flavor & Fragrance Mat Assoc, Chuo Ku, Sankeinihonbashi Bldg 6F,4-7-1 Nihonbashi Honcho, Tokyo 1030023, Japan

[8] Prod Safety Labs, 2394 US Highway 130, Dayton, NJ 08810 USA

[9] Symrise AG, Muehlenfeldstr 1, D-37603 Holzminden, Germany

[10] Int Flavors & Fragrances Inc, 1515 State Highway 36, Union Beach, NJ 07735 USA

[11] Coca Cola Co, POB 1734, Atlanta, GA 30301 USA

[12] Takasago Int Corp, 4 Volvo Dr, Rockleigh, NJ 07647 USA

[13] Givaudan Int SA, Winterthurerstr, Kemptthal, Switzerland

[14] Firmenich Inc, POB 5880, Princeton, NJ 08543 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2018年 / 120卷

关键词：

Methyl propyl trisulfide; Flavoring ingredient; FEMA GRAS; Rat; Toxicity; MULTIPLE COMPARISONS; HEMOLYTIC-ACTIVITY; POLYSULFIDES; DISULFIDES;

D O I：

10.1016/j.fct.2018.07.056

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Methyl propyl trisulfide is a flavoring substance found in foods such as garlic and onions. At the request of the European Food Safety Authority (EFSA) for additional toxicological data on methyl propyl trisulfide, groups of Sprague-Dawley rats (10/sex/group) were gavaged with 0 (corn oil vehicle control), 0.5, 2, or 6 mg methyl propyl trisulfide/kg bw/day in a 90-day GLP-compliant study. No effects on clinical observations, hematology and clinical chemistry parameters, organ weights, or macroscopic and histopathological examinations were found attributable to ingestion of methyl propyl trisulfide. The oral no-observed-adverse-effect level (NOAEL) for rats of both sexes was the highest dose tested of 6 mg/kg bw/day.

引用

页码：544 / 551

页数：8

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