Use of the Adamantane Structure in Medicinal Chemistry

被引：225

作者：

Lamoureux, Guy ^{[1
]}

Artavia, Graciela

机构：

[1] Univ Costa Rica, Escuela Quim, San Jose, Costa Rica

来源：

CURRENT MEDICINAL CHEMISTRY | 2010年 / 17卷 / 26期

关键词：

Adamantane; hydrophobic effects; ion channels; rigid scaffold; DIRECTED DRUG CARRIER; MALARIA-INFECTED MICE; POORLY ABSORBED DRUG; M2 PROTON CHANNEL; IN-VITRO; MULTIVALENT SCAFFOLDS; ION-CHANNEL; BIOLOGICAL EVALUATION; ANTIVIRAL AGENTS; VIRUS;

D O I：

10.2174/092986710792065027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review summarizes the importance and recent discoveries of the use of adamantane derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) Absorption, Distribution, Metabolism, or Excretion (ADME) properties 2) Hydrophobic Effects 3) Ion Channels and 4) Rigid scaffold. Within each section, we have provided examples of how the adamantane group changes the properties of known drugs or provides a important pharmacophore for the design of new drugs.

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页码：2967 / 2978

页数：12

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