Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin

被引:24
作者
Francisco Rodriguez-Landa, Juan [1 ,2 ]
Jesus German-Ponciano, Leon [1 ]
Puga-Olguin, Abraham [3 ]
Jeronimo Olmos-Vazquez, Oscar [1 ]
机构
[1] Univ Veracruzana, Inst Neuroetol, Lab Neurofarmacol, Xalapa 91190, Veracruz, Mexico
[2] Univ Veracruzana, Fac Quim Farmaceut Biol, Xalapa 91000, Veracruz, Mexico
[3] Univ Veracruzana, Ctr EcoAlfabetizac & Dialogo Saberes, Unidad Salud Integrat, Xalapa 91060, Veracruz, Mexico
来源
MOLECULES | 2022年 / 27卷 / 11期
关键词
antidepressant; anxiolytic; chrysin; flavonoid; natural medicine; neuropharmacology; CENTRAL BENZODIAZEPINE-RECEPTOR; DEPRESSIVE-LIKE BEHAVIOR; ANXIETY-LIKE BEHAVIOR; OXIDATIVE STRESS; MAJOR DEPRESSION; INFLAMMATORY CYTOKINES; SERUM-LEVELS; BRAIN; MICE; ATTENUATION;
D O I
10.3390/molecules27113551
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chrysin (5,7-dihydroxyflavone) is a flavonoid isolated from plants, such as Passiflora coerulea, Passiflora incarnata, and Matricaria chamomilla. This natural molecule exerts diverse pharmacological effects, which includes antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and anti-apoptotic effects. Additionally, in brain structures, such as the hippocampus, prefrontal cortex, raphe nucleus, and striatum, involved in the physiopathology of anxiety and depression disorders, several neuropharmacological activities, including the activation of neurotransmitter systems (GABAergic, serotonergic, dopaminergic, and noradrenergic), neurotrophic factors, such as brain-derived neurotrophic factor and the nerve growth factor, and some signaling pathways are affected. The results showed that the anxiolytic and antidepressant-like effects of chrysin occurs through its interaction with specific neurotransmitter systems, principally the GABAergic and the serotonergic, and activation of other neurotrophic factors. However, it is not possible to discard the antioxidant and anti-inflammatory activities of chrysin while producing its anxiolytic- and antidepressant-like effects. Although these results have been obtained principally from pre-clinical research, they consistently demonstrate the potential therapeutic use of flavonoid chrysin as an anxiolytic and antidepressant agent. Therefore, this flavonoid could be considered as a promising novel therapy for anxiety and depression disorders.
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页数:17
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