Quantitative determination of water in γ-cyclodextrin by near-infrared spectroscopy

被引：0
作者：
Viernstein, H
Weiss-Greiler, P
Wolschann, P
机构：
[1] Univ Vienna, Inst Pharmaceut Technol & Biopharm, Pharmaziezentrum, A-1090 Vienna, Austria
[2] Univ Vienna, Inst Theoret Chem & Struct Biol, Vienna, Austria
来源：
PHARMAZEUTISCHE INDUSTRIE | 2005年 / 67卷 / 01期
关键词：
CAS; 17465-86-0; cyclodextrins; gamma-cyclodextrin; quality control; water content; near infrared spectroscopy;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
gamma-Cyclodextrin (CAS 17465-86-0) is of increasing interest as excipient and additive for drugs, because of the higher solubility in water in comparison to beta-cyclodextrin (CAS 7585-39-9) and the very low toxicity. Commercially available gamma-cyclodextrin contains absorbed water. The quantitative determination of these amounts of water is important for the product specification as well as for the preparation of inclusion complexes. Near-Infrared Spectroscopy is a very convenient method for a fast and sufficiently accurate determination of the water content of gamma-cyclodextrin for the product specification as well as for the quality control of end products.
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页码：122 / 125
页数：6
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