Euphorbia royleana;
anti-inflammatory activity;
anti-arthritic activity;
D O I:
10.1016/S0367-326X(00)00225-2
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
The hydrosoluble fraction of Euphorbia royleana latex (AER), administered by gavage at doses of 50-200 mg/kg, showed dose-dependent anti-inflammatory and anti-arthritic effects in different acute and chronic test models in rats and mice. It reduced the exudate volume and the migration of leukocytes and showed a poor inhibitory effect on the granuloma formation induced by cotton pellets, while it had a low ulcerogenic score. The oral LD50 was more than 1500 mg/kg in both rats and mice. (C) 2000 Elsevier Science B.V. All rights reserved.
机构:
Univ Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, MalaysiaUniv Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, Malaysia
Emrizal
Ahmad, Farediah
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Univ Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, MalaysiaUniv Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, Malaysia
Ahmad, Farediah
Sirat, Hasnah M.
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Univ Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, MalaysiaUniv Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, Malaysia
Sirat, Hasnah M.
Jamaludin, Fadzureena
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FRIM, Kuala Lumpur 52109, MalaysiaUniv Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, Malaysia
Jamaludin, Fadzureena
Mustapha, Nik Musa'adah
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FRIM, Kuala Lumpur 52109, MalaysiaUniv Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, Malaysia
Mustapha, Nik Musa'adah
Ali, Rasadah M.
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FRIM, Kuala Lumpur 52109, MalaysiaUniv Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, Malaysia
Ali, Rasadah M.
Arbain, Dayar
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机构:
Andalas Univ, Dept Pharm, Fac Sci, Padang, IndonesiaUniv Teknol Malaysia, Dept Chem, Fac Sci, Skudai 81310, Johor Bahru, Malaysia
机构:
Indian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, IndiaIndian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, India
Muruganandan, S
Srinivasan, K
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Indian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, IndiaIndian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, India
Srinivasan, K
Chandra, S
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Indian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, IndiaIndian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, India
Chandra, S
Tandan, SK
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Indian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, IndiaIndian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, India
Tandan, SK
Lal, J
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Indian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, IndiaIndian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, India
Lal, J
Raviprakash, V
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Indian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, IndiaIndian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, India
机构:Shahid Beheshti University of Medical Sciences,Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine
Simzar Hosseinzadeh
Shokouhsadat Hamedi
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机构:Shahid Beheshti University of Medical Sciences,Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine
Shokouhsadat Hamedi
Elaheh Esmaeili
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机构:Shahid Beheshti University of Medical Sciences,Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine
Elaheh Esmaeili
Mahboubeh Kabiri
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机构:Shahid Beheshti University of Medical Sciences,Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine
Mahboubeh Kabiri
Ali Babaie
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机构:Shahid Beheshti University of Medical Sciences,Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine
Ali Babaie
Masoud Soleimani
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机构:Shahid Beheshti University of Medical Sciences,Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine
Masoud Soleimani
Abdolreza Ardeshirylajimi
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机构:Shahid Beheshti University of Medical Sciences,Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine