Anti-inflammatory activity of the hydrosoluble fraction of Euphorbia royleana latex

被引：24

作者：

Bani, S

Kaul, A

Jaggi, BS

Suri, KA

Suri, OP

Sharma, OP

机构：

[1] Reg Res Lab, Dept Pharmacol, Jammu 180001, India

[2] Reg Res Lab, Nat Prod Chem Div, Jammu 180001, India

[3] Univ Jammu, Dept Biosci, Jammu 180004, India

来源：

FITOTERAPIA | 2000年 / 71卷 / 06期

关键词：

Euphorbia royleana; anti-inflammatory activity; anti-arthritic activity;

D O I：

10.1016/S0367-326X(00)00225-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The hydrosoluble fraction of Euphorbia royleana latex (AER), administered by gavage at doses of 50-200 mg/kg, showed dose-dependent anti-inflammatory and anti-arthritic effects in different acute and chronic test models in rats and mice. It reduced the exudate volume and the migration of leukocytes and showed a poor inhibitory effect on the granuloma formation induced by cotton pellets, while it had a low ulcerogenic score. The oral LD50 was more than 1500 mg/kg in both rats and mice. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：655 / 662

页数：8

共 15 条

[1]

Agarwal V.S., 1986, EC PLANTS INDIA, VI, P135

[2] PHARMACOLOGY OF BENOXAPROFEN (2-[4-CHLOROPHENYL]-ALPHA-METHYL-5-BENZOXAZOLE ACETIC-ACID), LRCL-3794, A NEW COMPOUND WITH ANTI-INFLAMMATORY ACTIVITY APPARENTLY UNRELATED TO INHIBITION OF PROSTAGLANDIN SYNTHESIS [J].