Signal Transduction by Mitochondrial Oxidants

被引：312

作者：

Finkel, Toren ^{[1
]}

机构：

[1] NHLBI, Ctr Mol Med, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 07期

基金：

美国国家卫生研究院;

关键词：

HEMATOPOIETIC STEM-CELLS; HYPOXIA-INDUCIBLE FACTOR; OXIDATIVE STRESS; INFLAMMASOME ACTIVATION; RESPIRATORY-CHAIN; ROS PRODUCTION; DJ-1; METABOLISM; AUTOPHAGY; KINASE;

D O I：

10.1074/jbc.R111.271999

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The production of mitochondrial reactive oxygen species occurs as a consequence of aerobic metabolism. Mitochondrial oxidants are increasingly viewed less as byproducts of metabolism and more as important signaling molecules. Here, I review several notable examples, including the cellular response to hypoxia, aspects of innate immunity, the regulation of autophagy, and stem cell self-renewal capacity, where evidence suggests an important regulatory role for mitochondrial oxidants.

引用

收藏

页码：4434 / 4440

页数：7

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