Comparative genomic analysis of genes encoding translation elongation factor 1Bα in human and mouse shows EEF1B1 to be a recent retrotransposition event

被引：10

作者：

Chambers, DM ^{[1
]}

Rouleau, GA ^{[1
]}

Abbott, CM ^{[1
]}

机构：

[1] McGill Univ, Montreal Gen Hosp, Res Inst, Ctr Res Neurosci, Montreal, PQ H3G 1A4, Canada

来源：

GENOMICS | 2001年 / 77卷 / 03期

关键词：

translation; elongation; EEF1B; Eef1b; pseudogene; paralogue; gene mapping; amyotrophic lateral sclerosis; ALS2;

D O I：

10.1006/geno.2001.6626

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have characterized genomic loci encoding translation elongation factor 1B alpha (eEF1B alpha) in mice and humans. Mice have a single structural locus (named Eef1b2) spanning six exons, which is ubiquitously expressed and maps close to Casp8 on mouse chromosome 1, and a processed pseudogene. Humans have a single intron-containing locus, EEF1B2, which maps to 2q33, and an intronless paralogue expressed only in brain and muscle (EEF1B3). Another locus described previously, EEF1B1, is actually a processed pseudogene on chromosome 15 corresponding to an alternative splice form of EEF1B2. Our study illustrates the value of comparative mapping in distinguishing between processed pseudogenes and intronless paralogues.

引用

页码：145 / 148

页数：4

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