Gallic Acid: A Dietary Polyphenol that Exhibits Anti-neoplastic Activities by Modulating Multiple Oncogenic Targets

被引：29

作者：

Tuli, Hardeep Singh ^{[1
]}

Mistry, Hiral ^{[2
]}

Kaur, Ginpreet ^{[2
]}

Aggarwal, Diwakar ^{[1
]}

Garg, Vivek Kumar ^{[3
]}

Mittal, Sonam ^{[4
]}

Yerer, Mukerrem Betul ^{[5
]}

Sak, Katrin ^{[6
]}

Khan, Md Asaduzzaman ^{[7
]}

机构：

[1] Maharishi Markandeshwar Deemed Univ, Dept Biotechnol, Mullana Ambala, Haryana, India

[2] SVKMs NMIMS, Shobhaben Pratapbhai Patel Sch Pharm & Technol Ma, Mumbai 400056, Maharashtra, India

[3] Chandigarh Univ, Univ Inst Appl Hlth Sci, Dept Med Lab Technol, Mohali 140413, Punjab, India

[4] Jawaharlal Nehru Univ, Sch Biotechnol, New Delhi, India

[5] Erciyes Univ, Drug Applicat & Res Ctr, Fac Pharm, Dept Pharmacol, Kayseri, Turkey

[6] NGO Praeventio, EE-50407 Tartu, Estonia

[7] Southwest Med Univ, Res Ctr Preclin Med, Luzhou 646000, Peoples R China

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 03期

关键词：

Gallic acid; apoptosis; anti-proliferation; anti-angiogenesis; anti-metastasis; dietary polyphenol; NF-KAPPA-B; HUMAN HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER CELLS; HUMAN-MELANOMA CELLS; IN-VIVO; DOWN-REGULATION; INDUCED APOPTOSIS; MATRIX METALLOPROTEINASE-2; ASCORBIC-ACID; TUMOR-GROWTH;

D O I：

10.2174/1871520621666211119085834

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Phytochemicals are being used for thousands of years to prevent dreadful malignancy. Side effects of existing allopathic treatment have also initiated intense research in the field of bioactive phytochemicals. Gallic acid, a natural polyphenolic compound, exists freely as well as in polymeric forms. The anti-cancer properties of gallic acid are indomitable by a variety of cellular pathways such as induction of programmed cell death, cell cycle apprehension, reticence of vasculature and tumor migration, and inflammation. Furthermore, gallic acid is found to show synergism with other existing chemotherapeutic drugs. Therefore, the antineoplastic role of gallic acid suggests its promising therapeutic candidature in the near future. The present review describes all these aspects of gallic acid at a single platform. In addition nanotechnology-mediated approaches are also discussed to enhance bioavailability and therapeutic efficacy.

引用

页码：499 / 514

页数：16

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