Arterial Stiffness and Stroke in Sickle Cell Disease

被引：16

作者：

Belizna, Cristina ^{[1
,2
]}

Loufrani, Laurent ^{[2
]}

Ghali, Alaa ^{[1
]}

Lahary, Agnes ^{[3
]}

Primard, Etienne ^{[3
]}

Louvel, Jean-Pierre ^{[3
]}

Henrion, Daniel ^{[2
]}

Levesque, Herve ^{[3
]}

Ifrah, Norbert ^{[1
]}

机构：

[1] Univ Hosp, F-49000 Angers, France

[2] INSERM 771, Angers, France

[3] Univ Hosp, Rouen, France

来源：

STROKE | 2012年 / 43卷 / 04期

关键词：

arterial stiffness; sickle cell disease; stroke; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; ADULT PATIENTS; VASCULOPATHY;

D O I：

10.1161/STROKEAHA.111.635383

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Large vessels are also affected in sickle cell disease. The aim of this study was to assess several parameters in adult patients with sickle cell disease compared with control subjects and in patients with sickle cell disease with stroke. Methods-Carotid arterial stiffness, intima-media thickness, and transcranial Doppler ultrasonography were measured. Results-Arterial stiffness and transcranial Doppler velocity were significantly increased in 49 patients with sickle cell disease compared with 47 control subjects (P<0.05) and especially in patients with stroke (P<0.05). Conclusions-These data suggest that transcranial Doppler and arterial stiffness might be associated to stroke in adult patients with sickle cell disease. (Stroke. 2012;43:1129-1130.)

引用

收藏

页码：1129 / 1130

页数：2

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