Is birth a critical period in the pathogenesis of autism spectrum disorders?

被引：89

作者：

Ben-Ari, Yehezkel ^{[1
,2
]}

机构：

[1] INSERM, INMED, U901, Neurochlore, F-13273 Marseille 09, France

[2] Aix Marseille Univ, F-13273 Marseille 09, France

来源：

NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 08期

关键词：

ALTERED CHLORIDE HOMEOSTASIS; SPONTANEOUS RETINAL ACTIVITY; CL COTRANSPORTER KCC2; SMOOTH-MUSCLE-CELLS; SPINAL-CORD-INJURY; NEURONAL MIGRATION; CATECHOLAMINE RELEASE; NMDA RECEPTORS; GANGLION-CELLS; DEVELOPING HIPPOCAMPUS;

D O I：

10.1038/nrn3956

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Birth is associated with a neuroprotective, oxytocin-mediated abrupt excitatory-to-inhibitory GABA shift that is abolished in autism, and its restoration attenuates the disorder in offspring. In this Opinion article, I discuss the links between birth-related stressful mechanisms, persistent excitatory GABA actions, perturbed network oscillations and autism. I propose that birth (parturition) is a critical period that confirms, attenuates or aggravates the deleterious effects of intrauterine genetic or environmental insults.

引用

页码：498 / 505

页数：8

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