Is birth a critical period in the pathogenesis of autism spectrum disorders?

被引：89

作者：

Ben-Ari, Yehezkel ^{[1
,2
]}

机构：

[1] INSERM, INMED, U901, Neurochlore, F-13273 Marseille 09, France

[2] Aix Marseille Univ, F-13273 Marseille 09, France

来源：

NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 08期

关键词：

ALTERED CHLORIDE HOMEOSTASIS; SPONTANEOUS RETINAL ACTIVITY; CL COTRANSPORTER KCC2; SMOOTH-MUSCLE-CELLS; SPINAL-CORD-INJURY; NEURONAL MIGRATION; CATECHOLAMINE RELEASE; NMDA RECEPTORS; GANGLION-CELLS; DEVELOPING HIPPOCAMPUS;

D O I：

10.1038/nrn3956

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Birth is associated with a neuroprotective, oxytocin-mediated abrupt excitatory-to-inhibitory GABA shift that is abolished in autism, and its restoration attenuates the disorder in offspring. In this Opinion article, I discuss the links between birth-related stressful mechanisms, persistent excitatory GABA actions, perturbed network oscillations and autism. I propose that birth (parturition) is a critical period that confirms, attenuates or aggravates the deleterious effects of intrauterine genetic or environmental insults.

引用

页码：498 / 505

页数：8

共 158 条

[1] Abnormal Network Activity in a Targeted Genetic Model of Human Double Cortex [J].

Ackman, James B. ;

Aniksztejn, Laurent ;

Crepel, Valerie ;

Becq, Helene ;

Pellegrino, Christophe ;

Cardoso, Carlos ;

Ben-Ari, Yehezkel ;

Represa, Alfonso .

JOURNAL OF NEUROSCIENCE, 2009, 29 (02) :313-327

[2] Transient tachypnea of the newborn (TTN):: A role for polymorphisms in the β-adrenergic receptor (ADRB) encoding genes? [J].

Aslan, Ece ;

Tutdibi, Erol ;

Martens, Swantje ;

Han, Yihua ;

Monz, Dominik ;

Gortner, Ludwig .

ACTA PAEDIATRICA, 2008, 97 (10) :1346-1350

[3] Coincident pre- and postsynaptic activity downregulates NKCC1 to hyperpolarize ECl during development [J].

Balena, Trevor ;

Woodin, Melanie A. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 27 (09) :2402-2412

[4] Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus [J].

Barmashenko, Gleb ;

Hefft, Stefan ;

Aertsen, Ad ;

Kirschstein, Timo ;

Koehling, Ruediger .

EPILEPSIA, 2011, 52 (09) :1570-1578

[5] Experimental evidence for sparse firing in the neocortex [J].

Barth, Alison L. ;

Poulet, James F. A. .

TRENDS IN NEUROSCIENCES, 2012, 35 (06) :345-355

[6] The mGIuR theory of fragile X mental retardation [J].

Bear, MF ;

Huber, KM ;

Warren, ST .

TRENDS IN NEUROSCIENCES, 2004, 27 (07) :370-377

[7] THE GABA EXCITATORY/INHIBITORY DEVELOPMENTAL SEQUENCE: A PERSONAL JOURNEY [J].

Ben-Ari, Y. .

NEUROSCIENCE, 2014, 279 :187-219

[8] GABA: A pioneer transmitter that excites immature neurons and generates primitive oscillations [J].

Ben-Ari, Yehezkel ;

Gaiarsa, Jean-Luc ;

Tyzio, Roman ;

Khazipov, Rustem .

PHYSIOLOGICAL REVIEWS, 2007, 87 (04) :1215-1284

[9] Phenotypic checkpoints regulate neuronal development [J].

Ben-Ari, Yehezkel ;

Spitzer, Nicholas C. .

TRENDS IN NEUROSCIENCES, 2010, 33 (11) :485-492

[10] Neuro-archaeology: pre-symptomatic architecture and signature of neurological disorders [J].

Ben-Ari, Yehezkel .

TRENDS IN NEUROSCIENCES, 2008, 31 (12) :626-636

← 1 2 3 4 5 6 7 8 9 10 →