Suboptimal glycemic control in type 2 diabetes: A key role for anhedonia?

被引:42
作者
Nefs, G. [1 ]
Pouwer, F. [1 ]
Denollet, J. [1 ]
Kramer, H. [2 ]
Wijnands-van Gent, C. J. M. [3 ]
Pop, V. J. M. [1 ]
机构
[1] Tilburg Univ, Dept Med Psychol & Neuropsychol, CoRPS Ctr Res Psychol Somat diseases, NL-5000 LE Tilburg, Netherlands
[2] Emergis, Goes, Netherlands
[3] Praktijkondersteuning Zuidoost Brabant, Veldhoven, Netherlands
关键词
Depression; Anhedonia; Glycemic control; Type; 2; diabetes; POSTNATAL DEPRESSION SCALE; REDUCED POSITIVE AFFECT; SYMPTOMS; RISK; VALIDATION; MORTALITY; EVENTS; ASSOCIATION; OUTCOMES; ANXIETY;
D O I
10.1016/j.jpsychires.2012.01.013
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Recent studies examining the relationship between depression and glycosylated hemoglobin (HbA(1c)) concentrations in patients with type 2 diabetes have yielded mixed findings. One explanation may lie in the heterogeneity of depression. Therefore, we examined whether distinct features of depression were differentially associated with suboptimal glycemic control. Cross-sectional baseline data from a dynamic cohort study of primary care patients with type 2 diabetes from the Eindhoven region, The Netherlands, were analyzed. A total of 5772 individuals completed baseline measurements of demographic, clinical, lifestyle and psychological factors between 2005 and 2009. The Edinburgh Depression Scale was used to assess symptoms of depressed mood, anhedonia and anxiety. Suboptimal glycemic control was defined as HbA(1c) values >= 7%, with 29.8% of the sample (n = 1718) scoring above this cut-off. In univariate logistic regression analyses, anhedonia was significantly associated with suboptimal glycemic control (OR 1.29, 95% CI 1.09-1.52), while both depressed mood (OR 1.04, 0.88-1.22) and anxiety (OR 0.99, 0.83-1.19) were not. The association between anhedonia and glycemic control remained after adjustment for the other depression measures (OR 1.33, 1.11-1.59). Alcohol consumption and physical activity met criteria for mediation, but did not attenuate the association between anhedonia and glycemic control by more than 5%. Although diabetes duration was identified as a confounder and controlled for, the association was still significant (OR 1.20, 1.01-1.43). Studying different symptoms of depression, in particular anhedonia, may add to a better understanding of the relationship between depression and glycemic control. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:549 / 554
页数:6
相关论文
共 41 条
[1]   The prevalence of co-morbid depression in adults with Type 2 diabetes: a systematic review and meta-analysis [J].
Ali, S. ;
Stone, M. A. ;
Peters, J. L. ;
Davies, M. J. ;
Khunti, K. .
DIABETIC MEDICINE, 2006, 23 (11) :1165-1173
[2]  
Amer Diabet Assoc, 2011, DIABETES CARE, V34, pS11, DOI [10.2337/dc10-S062, 10.2337/dc14-S081, 10.2337/dc11-S011, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc10-S011, 10.2337/dc12-s011]
[3]   Anxiety and poor glycemic control: A meta-analytic review of the literature [J].
Anderson, RJ ;
Grigsby, AB ;
Freedland, KE ;
de Groot, M ;
McGill, JB ;
Clouse, RE ;
Lustman, PJ .
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE, 2002, 32 (03) :235-247
[4]  
[Anonymous], 2000, FORCE DSM 4 DSM 4 T, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
[5]  
[Anonymous], 2000, WHO TECHN REP SER, V894, pi, DOI DOI 10.1596/0-1952-1129-4
[6]  
Barbee J G, 1998, Ann Clin Psychiatry, V10, P15, DOI 10.3109/10401239809148814
[7]   THE MODERATOR MEDIATOR VARIABLE DISTINCTION IN SOCIAL PSYCHOLOGICAL-RESEARCH - CONCEPTUAL, STRATEGIC, AND STATISTICAL CONSIDERATIONS [J].
BARON, RM ;
KENNY, DA .
JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY, 1986, 51 (06) :1173-1182
[8]   Measuring depression in women around menopausal age. Towards a validation of the Edinburgh Depression Scale [J].
Becht, MC ;
Van Erp, CF ;
Teeuwisse, TM ;
Van Heck, GL ;
Van Son, MJ ;
Pop, VJ .
JOURNAL OF AFFECTIVE DISORDERS, 2001, 63 (1-3) :209-213
[9]   Depression predicts increased incidence of adverse health outcomes in older Mexican Americans with type 2 diabetes [J].
Black, SA ;
Markides, KS ;
Ray, LA .
DIABETES CARE, 2003, 26 (10) :2822-2828
[10]   What symptoms of depression predict mortality in community-dwelling elders? [J].
Blazer, DG ;
Hybels, CF .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2004, 52 (12) :2052-2056