Neurocognitive performance after PCSK9 inhibitor therapy: Current state of the evidence

被引:1
作者
Stamerra, Cosimo Andrea [1 ]
Di Giosia, Paolo [1 ]
Giorgini, Paolo [1 ]
De Feo, Martina [1 ]
Grassi, Davide [1 ]
Ferri, Claudio [1 ]
Sahebkar, Amirhossein [2 ,3 ]
机构
[1] Univ Aquila, Dept Life Hlth & Environm Sci, Laquila, Italy
[2] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
[3] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran
关键词
atherosclerosis; statins; lipids; neurocognitive events; PCSK9; inhibitors; SECONDARY PREVENTION; ALZHEIMERS-DISEASE; COGNITIVE FUNCTION; BRAIN CHOLESTEROL; LDL-CHOLESTEROL; EVOLOCUMAB; HYPERCHOLESTEROLEMIA; EFFICACY; SAFETY; METAANALYSIS;
D O I
10.1002/jnr.24199
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:762 / 764
页数:3
相关论文
共 35 条
[1]   Hypercholesterolaemia and vascular dementia [J].
Appleton, Jason P. ;
Scutt, Polly ;
Sprigg, Nikola ;
Bath, Philip M. .
CLINICAL SCIENCE, 2017, 131 (14) :1561-1578
[2]   Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials [J].
Baigent, C. ;
Blackwell, L. ;
Emberson, J. ;
Holland, L. E. ;
Reith, C. ;
Bhala, N. ;
Peto, R. ;
Barnes, E. H. ;
Keech, A. ;
Simes, J. ;
Collins, R. .
LANCET, 2010, 376 (9753) :1670-1681
[3]   Brain cholesterol:: Long secret life behind a barrier [J].
Björkhem, I ;
Meaney, S .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (05) :806-815
[4]   A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia [J].
Blom, Dirk J. ;
Hala, Tomas ;
Bolognese, Michael ;
Lillestol, Michael J. ;
Toth, Phillip D. ;
Burgess, Lesley ;
Ceska, Richard ;
Roth, Eli ;
Koren, Michael J. ;
Ballantyne, Christie M. ;
Monsalvo, Maria Laura ;
Tsirtsonis, Kate ;
Kim, Jae B. ;
Scott, Rob ;
Wasserman, Scott M. ;
Stein, Evan A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (19) :1809-1819
[5]   Alzheimer's disease and cholesterol: The fat connection [J].
Canevari, Laura ;
Clark, John B. .
NEUROCHEMICAL RESEARCH, 2007, 32 (4-5) :739-750
[6]   Efficacy and safety profile of evolocumab (AMG145), an injectable inhibitor of the proprotein convertase subtilisin/kexin type 9: the available clinical evidence [J].
Cicero, Arrigo F. G. ;
Tartagni, Elisa ;
Ertek, Sibel .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2014, 14 (06) :863-868
[7]   Retargeting the management of hypercholesterolemia - focus on evolocumab [J].
Colletti, Alessandro ;
Derosa, Giuseppe ;
Cicero, Arrigo F. G. .
THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2016, 12 :1365-1376
[8]  
Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3
[9]   Long-Term Effects of Secondary Prevention on Cognitive Function in Stroke Patients [J].
Douiri, Abdel ;
McKevitt, Christopher ;
Emmett, Eva S. ;
Rudd, Anthony G. ;
Wolfe, Charles D. A. .
CIRCULATION, 2013, 128 (12) :1341-1348
[10]   Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapyA cognitive study of patients enrolled in the FOURIER trial [J].
Giugliano, Robert P. ;
Mach, Francois ;
Zavitz, Kenton ;
Kurtz, Christopher ;
Schneider, Jingjing ;
Wang, Huei ;
Keech, Anthony ;
Pedersen, Terje R. ;
Sabatine, Marc S. ;
Sever, Peter S. ;
Honarpour, Narimon ;
Wasserman, Scott M. ;
Ott, Brian R. .
CLINICAL CARDIOLOGY, 2017, 40 (02) :59-65