Advances in intravesical therapy for bladder pain syndrome (BPS)/interstitial cystitis (IC)

被引:31
作者
Meng, En [1 ]
Hsu, Yu-Chao [2 ,3 ]
Chuang, Yao-Chi [4 ]
机构
[1] Triserv Gen Hosp, Natl Def Med Ctr, Dept Urol, Taipei, Taiwan
[2] Linko Chang Gung Mem Hosp, Dept Urol, Taipei, Taiwan
[3] Chang Gung Univ, Coll Med, Taipei, Taiwan
[4] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Urol, 123 Dapi Rd, Kaohsiung 833, Taiwan
关键词
bladder pain syndrome; interstitial cystitis; intravesical therapy; BOTULINUM-TOXIN-A; PENTOSAN POLYSULFATE SODIUM; INTERSTITIAL CYSTITIS; SYNDROME/INTERSTITIAL CYSTITIS; HYALURONIC-ACID; CHONDROITIN SULFATE; DOUBLE-BLIND; DIMETHYL-SULFOXIDE; DETRUSOR OVERACTIVITY; ALKALINIZED LIDOCAINE;
D O I
10.1111/luts.12214
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a chronic symptom complex that may cause bothersome storage symptoms and pain or discomfort of the bladder, adversely affecting a patient's quality of life. The etiology of IC/BPS remains unclear, and its cause may be multifactorial. Diagnosis of IC/BPS is based on clinical features, and the possibility of other conditions must be ruled out first. Although no definitive treatment is currently available for IC/BPS, various intravesical therapies are used for IC/BPS, including heparin, hyaluronic acid, chondroitin sulfate, pentosan polysulfate, dimethylsulfoxide, liposomes, and botulinum onabotulinumtoxinA (BoNT-A). This review summarizes the intravesical therapy for IC/BPS and discusses recent advances in the instillation of liposomal-mediated BoNT-A and other newly developed intravesical therapies.
引用
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页码:3 / 11
页数:9
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