Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells

被引：35

作者：

Ge, Yakun ^{[1
,2
]}

Zhang, Yuanxin ^{[1
,2
]}

Chen, Yunpeng ^{[3
]}

Li, Quanshun ^{[1
]}

Chen, Jun ^{[4
]}

Dong, Ying ^{[4
]}

Shi, Wei ^{[1
]}

机构：

[1] Jilin Univ, Sch Life Sci, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun 130023, Peoples R China

[2] Jilin Inst Chem Technol, Coll Environm & Biol Engn, Jilin 132022, Peoples R China

[3] Jilin Univ, Coll Pharm, Ctr Combinatorial Chem & Drug Discovery, Changchun 130021, Peoples R China

[4] Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 08期

关键词：

Silibinin; cell proliferation; apoptosis; cell-cycle arrest; pancreatic cancer; DEPENDENT KINASE INHIBITORS; DOWN-REGULATING SURVIVIN; SILYMARIN; DEATH; EXPRESSION; INDUCTION; GROWTH; P53;

D O I：

10.3390/ijms12084861

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated. Here, we evaluated the inhibitory proliferation effects of Silibinin in pancreatic carcinoma growth and examined whether Silibinin modulates cell cycle and apoptosis. Our results indicate that Silibinin effectively inhibited the pancreatic carcinoma AsPC-1, BxPC-3 and Panc-1 cells' proliferation and caused apoptosis. Silibinin induced a decrease in S phase and cell cycle arrest in G1 phase in AsPC-1 cells, but had no obvious changes in BxPC-3 and Panc-1 cell cycle. Furthermore, these results suggest that Silibinin might be a candidate chemopreventive agent for pancreatic carcinoma therapy.

引用

页码：4861 / 4871

页数：11

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