Humic Acid and Glucan: Protection Against Liver Injury Induced by Carbon Tetrachloride

被引：7
作者：
Vetvicka, Vaclav [1 ]
Garcia-Mina, Jose M. [2 ,3 ]
Proctor, Mary [4 ]
Yvin, Jean-Claude [5 ]
机构：
[1] Univ Louisville, Dept Pathol, Louisville, KY 40202 USA
[2] Poligono Arazuri Orcoyen, R&D Dept, Timac Agro Int Roullier Grp, Orcoyen, Spain
[3] Univ Navarra, Dept Chem & Soil Chem, Navarra, Spain
[4] Univ Louisville, Res Resource Ctr, Louisville, KY 40202 USA
[5] Timac Agro Int, R&D Dept, Dinard, France
来源：
JOURNAL OF MEDICINAL FOOD | 2015年 / 18卷 / 05期
关键词：
liver; glucan; CCL4; hepatotoxicity; humic acids; HEPATOPROTECTIVE ACTIVITY; COMBINATION; RESVERATROL; INHIBITION; SUPPRESSES; TOXICITY; FIBROSIS; EXTRACT; OXYGEN; MICE;
D O I：
10.1089/jmf.2014.0091
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Humic acids (HAs) have a rather pleiotropic presence, however, their biological effects are still unclear. In this study, we focused on possible hepatoprotective effects of either HA alone or in combination with beta-glucan. Using a model of experimental hepatotoxicity caused by carbon tetrachloride (CCL4), we showed that both HA and the glucan-HA combination offered significant protection against hepatotoxicity, with the combination offering superior effects. Our biochemical observations were confirmed by histological evaluation. Based on the experimental data, we conclude that whereas HA has significant effects, the synergy with glucan offers superior effects.
引用
收藏
页码：572 / 577
页数：6
相关论文
共 34 条
[1]   RETRACTED: Diet Restriction Inhibits Apoptosis and HMGB1 Oxidation and Promotes Inflammatory Cell Recruitment during Acetaminophen Hepatotoxicity (Publication with Expression of Concern. See vol. 26, 2020) (Retracted article. See vol. 26, 2020) [J].
Antoine, Daniel James ;
Williams, Dominic P. ;
Kipar, Anja ;
Laverty, Hugh ;
Park, B. Kevin .
MOLECULAR MEDICINE, 2010, 16 (11-12) :479-490
[2]   Pharmacological Inhibition of the Chemokine C-C Motif Chemokine Ligand 2 (Monocyte Chemoattractant Protein 1) Accelerates Liver Fibrosis Regression by Suppressing Ly-6C+ Macrophage Infiltration in Mice [J].
Baeck, Christer ;
Wei, Xiao ;
Bartneck, Matthias ;
Fech, Viktor ;
Heymann, Felix ;
Gassler, Nikolaus ;
Hittatiya, Kanishka ;
Eulberg, Dirk ;
Luedde, Tom ;
Trautwein, Christian ;
Tacke, Frank .
HEPATOLOGY, 2014, 59 (03) :1060-1072
[3]   Industrial solvents and liver toxicity: Risk assessment, risk factors and mechanisms [J].
Brautbar, N ;
Williams, J .
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2002, 205 (06) :479-491
[4]   ROLE OF FREE-RADICALS IN TOXIC HEPATIC-INJURY .2. ARE FREE-RADICALS THE CAUSE OF TOXIN-INDUCED LIVER-INJURY [J].
BRENT, JA ;
RUMACK, BH .
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 1993, 31 (01) :173-196
[5]   Effects of Dietary Humic Acid and Saccharomyces cerevisiae on Performance and Biochemical Parameters of Broiler Chickens [J].
Celik, Kemal ;
Uzatici, Ahmet ;
Akin, Adil Erdem .
ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2008, 3 (05) :344-350
[6]  
Chen CL, 2003, CIRCULATION, V108, P108
[7]   Modulation of liver fibrosis and pathophysiological changes in mice infected with Mesocestoides corti (M-vogae) after administration of glucan and liposomized glucan in combination with vitamin C [J].
Ditteová, G ;
Velebny, S ;
Hrckova, G .
JOURNAL OF HELMINTHOLOGY, 2003, 77 (03) :219-226
[8]  
Ferreira EA, 2010, LIBYAN J MED, DOI [10.3402/ljm.v510.4891, DOI 10.3402/LJM.V510.4891]
[9]   Main binding sites involved in Fe(III) and Cu(II) complexation in humic-based structures [J].
Fuentes, Marta ;
Olaetxea, Maite ;
Baigorri, Roberto ;
Zamarreno, Angel M. ;
Etienne, Philippe ;
Laine, Philippe ;
Ourry, Alain ;
Yvin, Jean-Claude ;
Garcia-Mina, Jose M. .
JOURNAL OF GEOCHEMICAL EXPLORATION, 2013, 129 :14-17
[10]   Humic acid suppresses the LPS-induced expression of cell-surface adhesion proteins through the inhibition of NF-κB activation [J].
Gau, RJ ;
Yang, HL ;
Chow, SN ;
Suen, JL ;
Lu, FJ .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2000, 166 (01) :59-67
1234