Purpose The effectiveness of base isolation in composite buildings is evaluated by comparing the vibration seismic responses of three considered building types, namely reinforced concrete (RC) buildings, fixed-base composite buildings, and the base-isolated composite buildings using lead rubber bearing (LRB) base isolators. Methods The response spectrum analysis is done to find the seismic response of considered buildings for this study. The effect of storey levels in the three different types of considered buildings was also examined by considering three different storey levels that are, namely three-storey, six-storey, and nine-storey buildings. Results The results obtained were compared for six seismic response parameters such as base shear, storey displacement, isolator displacement, storey drift, and column axial forces, column bending moments in all three types of buildings. Conclusions The study concludes that the overall performance of base-isolated composite buildings in all three-, six-, and nine-storey buildings is best than RCC and fixed-base composite buildings since this is the integrated application of base isolation and composite building. The fixed-base composite buildings outperform RCC buildings in all three levels of storeys, making base-isolated composite buildings the perfect option for high-rise, mid-rise, and low-rise buildings.