BiomMiner: An advanced exploratory microbiome analysis and visualization pipeline

被引:19
作者
Shamsaddini, Amirhossein [1 ]
Dadkhah, Kimia [1 ]
Gillevet, Patrick M. [1 ]
机构
[1] George Mason Univ, Microbiome Anal Ctr, Manassas, VA 20110 USA
关键词
STATISTICAL-ANALYSIS; GUT MICROBIOME; DIVERSITY;
D O I
10.1371/journal.pone.0234860
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Current microbiome applications require substantial bioinformatics expertise to execute. As microbiome clinical diagnostics are being developed, there is a critical need to implement computational tools and applications that are user-friendly for the medical community to understand microbiome correlation with the health. To address this need, we have developed BiomMiner (pronounced as "biominer"), an automated pipeline that provides a comprehensive analysis of microbiome data. The pipeline finds taxonomic signatures of microbiome data and compiles actionable clinical report that allows clinicians and biomedical scientists to efficiently perform statistical analysis and data mining on the large microbiome datasets. BiomMiner generates web-enabled visualization of the analysis results and is specifically designed to facilitate the use of microbiome datasets in clinical applications.
引用
收藏
页数:13
相关论文
共 35 条
[1]   A new method for non-parametric multivariate analysis of variance [J].
Anderson, MJ .
AUSTRAL ECOLOGY, 2001, 26 (01) :32-46
[2]  
[Anonymous], 2015, J PROTEOMICS BIOINFO, DOI 10.4172/0974-276X.1000381
[3]   Enterotypes of the human gut microbiome [J].
Arumugam, Manimozhiyan ;
Raes, Jeroen ;
Pelletier, Eric ;
Le Paslier, Denis ;
Yamada, Takuji ;
Mende, Daniel R. ;
Fernandes, Gabriel R. ;
Tap, Julien ;
Bruls, Thomas ;
Batto, Jean-Michel ;
Bertalan, Marcelo ;
Borruel, Natalia ;
Casellas, Francesc ;
Fernandez, Leyden ;
Gautier, Laurent ;
Hansen, Torben ;
Hattori, Masahira ;
Hayashi, Tetsuya ;
Kleerebezem, Michiel ;
Kurokawa, Ken ;
Leclerc, Marion ;
Levenez, Florence ;
Manichanh, Chaysavanh ;
Nielsen, H. Bjorn ;
Nielsen, Trine ;
Pons, Nicolas ;
Poulain, Julie ;
Qin, Junjie ;
Sicheritz-Ponten, Thomas ;
Tims, Sebastian ;
Torrents, David ;
Ugarte, Edgardo ;
Zoetendal, Erwin G. ;
Wang, Jun ;
Guarner, Francisco ;
Pedersen, Oluf ;
de Vos, Willem M. ;
Brunak, Soren ;
Dore, Joel ;
Weissenbach, Jean ;
Ehrlich, S. Dusko ;
Bork, Peer .
NATURE, 2011, 473 (7346) :174-180
[4]   DIVERSITY OF PLANKTONIC FORAMINIFERA IN DEEP-SEA SEDIMENTS [J].
BERGER, WH ;
PARKER, FL .
SCIENCE, 1970, 168 (3937) :1345-+
[5]   AN ORDINATION OF THE UPLAND FOREST COMMUNITIES OF SOUTHERN WISCONSIN [J].
BRAY, JR ;
CURTIS, JT .
ECOLOGICAL MONOGRAPHS, 1957, 27 (04) :326-349
[6]   A guide to statistical analysis in microbial ecology: a community-focused, living review of multivariate data analyses [J].
Buttigieg, Pier Luigi ;
Ramette, Alban .
FEMS MICROBIOLOGY ECOLOGY, 2014, 90 (03) :543-550
[7]   QIIME allows analysis of high-throughput community sequencing data [J].
Caporaso, J. Gregory ;
Kuczynski, Justin ;
Stombaugh, Jesse ;
Bittinger, Kyle ;
Bushman, Frederic D. ;
Costello, Elizabeth K. ;
Fierer, Noah ;
Pena, Antonio Gonzalez ;
Goodrich, Julia K. ;
Gordon, Jeffrey I. ;
Huttley, Gavin A. ;
Kelley, Scott T. ;
Knights, Dan ;
Koenig, Jeremy E. ;
Ley, Ruth E. ;
Lozupone, Catherine A. ;
McDonald, Daniel ;
Muegge, Brian D. ;
Pirrung, Meg ;
Reeder, Jens ;
Sevinsky, Joel R. ;
Tumbaugh, Peter J. ;
Walters, William A. ;
Widmann, Jeremy ;
Yatsunenko, Tanya ;
Zaneveld, Jesse ;
Knight, Rob .
NATURE METHODS, 2010, 7 (05) :335-336
[8]   A new statistical approach for assessing similarity of species composition with incidence and abundance data [J].
Chao, A ;
Chazdon, RL ;
Colwell, RK ;
Shen, TJ .
ECOLOGY LETTERS, 2005, 8 (02) :148-159
[9]   ESTIMATING THE NUMBER OF CLASSES VIA SAMPLE COVERAGE [J].
CHAO, A ;
LEE, SM .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1992, 87 (417) :210-217
[10]   NONPARAMETRIC MULTIVARIATE ANALYSES OF CHANGES IN COMMUNITY STRUCTURE [J].
CLARKE, KR .
AUSTRALIAN JOURNAL OF ECOLOGY, 1993, 18 (01) :117-143