Therapy and clinical trials in frontotemporal dementia: past, present, and future

被引：99
作者：
Tsai, Richard M. [1 ]
Boxer, Adam L. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Neurol, Neurol, 675 Nelson Rising Lane,Suite 190, San Francisco, CA 94115 USA
来源：
JOURNAL OF NEUROCHEMISTRY | 2016年 / 138卷
关键词：
frontotemporal dementia; clinical trials; treatment; 10th International Conference on Frontotemporal Dementia; behavioral variant frontotemporal dementia (bvFTD); primary progressive aphasia (PPA); progressive supranuclear palsy (PSP); tau; TDP-43; C9ORF72; PRIMARY-PROGRESSIVE-APHASIA; POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL GLUCOSE-METABOLISM; HEXANUCLEOTIDE REPEAT EXPANSION; LOBAR DEGENERATION SPECTRUM; VOXEL-BASED MORPHOMETRY; WHITE-MATTER DAMAGE; PHF-TAU RADIOLIGAND; ALZHEIMERS-DISEASE; BEHAVIORAL VARIANT;
D O I：
10.1111/jnc.13640
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Frontotemporal dementia (FTD) is a common form of dementia with heterogeneous clinical presentations and distinct clinical syndromes. This article will review currently available therapies for FTD, its related disorders and their clinical evidence. It will also discuss recent advancements in FTD pathophysiology, treatment development, biomarker advancement and their relation to recently completed or currently ongoing clinical trials as well as future implications.
引用
收藏
页码：211 / 221
页数：11
相关论文
共 128 条
[11]   The arcuate fasciculus and the disconnection theme in language and aphasia: History and current state [J].
Catani, Marco ;
Mesulam, Marsel .
CORTEX, 2008, 44 (08) :953-961
[12]   The behavioral variant of frontotemporal dementia: linking neuropathology to social cognition [J].
Cerami, Chiara ;
Cappa, Stefano F. .
NEUROLOGICAL SCIENCES, 2013, 34 (08) :1267-1274
[13]   Rates of global and regional cerebral atrophy in AD and frontotemporal dementia [J].
Chan, D ;
Fox, NC ;
Jenkins, R ;
Scahill, RI ;
Crum, WR ;
Rossor, MN .
NEUROLOGY, 2001, 57 (10) :1756-1763
[14]   The clinical profile of right temporal lobe atrophy [J].
Chan, Dennis ;
Anderson, Valerie ;
Pijnenburg, Yolande ;
Whitwell, Jennifer ;
Barnes, Jo ;
Scahill, Rachael ;
Stevens, John M. ;
Barkhof, Frederik ;
Scheltens, Philip ;
Rossor, Martin N. ;
Fox, Nick C. .
BRAIN, 2009, 132 :1287-1298
[15]   Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808 [J].
Chien, David T. ;
Szardenings, A. Katrin ;
Bahri, Shadfar ;
Walsh, Joseph C. ;
Mu, Fanrong ;
Xia, Chunfang ;
Shankle, William R. ;
Lerner, Alan J. ;
Su, Min-Ying ;
Elizarova, Arkadij ;
Kolb, Hartmuth C. .
JOURNAL OF ALZHEIMERS DISEASE, 2014, 38 (01) :171-184
[16]   Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807 [J].
Chien, David T. ;
Bahri, Shadfar ;
Szardenings, A. Katrin ;
Walsh, Joseph C. ;
Mu, Fanrong ;
Su, Min-Ying ;
Shankle, William R. ;
Elizarov, Arkadij ;
Kolb, Hartmuth C. .
JOURNAL OF ALZHEIMERS DISEASE, 2013, 34 (02) :457-468
[17]   A comparison of FDG-PET and blood flow SPECT in the diagnosis of neurodegenerative dementias: a systematic review [J].
Davison, Christopher M. ;
O'Brien, John T. .
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2014, 29 (06) :551-561
[18]   Prediction of pathology in primary progressive language and speech disorders [J].
Deramecourt, V. ;
Lebert, F. ;
Debachy, B. ;
Mackowiak-Cordoliani, M. A. ;
Bombois, S. ;
Kerdraon, O. ;
Buee, L. ;
Maurage, C. -A. ;
Pasquier, F. .
NEUROLOGY, 2010, 74 (01) :42-49
[19]   Anatomical and functional alterations in semantic dementia:: A voxel-based MRI and PET study [J].
Desgranges, Béatrice ;
Matuszewski, Vanessa ;
Piolino, Pascale ;
Chételat, Gaël ;
Mézenge, Florence ;
Landeau, Brigitte ;
De la Sayette, Vincent ;
Belliard, Serge ;
Eustache, Francis .
NEUROBIOLOGY OF AGING, 2007, 28 (12) :1904-1913
[20]   Neuropathology of variants of progressive supranuclear palsy [J].
Dickson, Dennis W. ;
Ahmed, Zeshan ;
Algom, Avi A. ;
Tsuboi, Yoshio ;
Josephs, Keith A. .
CURRENT OPINION IN NEUROLOGY, 2010, 23 (04) :394-400
12345678910