Therapy and clinical trials in frontotemporal dementia: past, present, and future

被引：99

作者：

Tsai, Richard M. ^{[1
]}

Boxer, Adam L. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, Neurol, 675 Nelson Rising Lane,Suite 190, San Francisco, CA 94115 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 2016年 / 138卷

关键词：

frontotemporal dementia; clinical trials; treatment; 10th International Conference on Frontotemporal Dementia; behavioral variant frontotemporal dementia (bvFTD); primary progressive aphasia (PPA); progressive supranuclear palsy (PSP); tau; TDP-43; C9ORF72; PRIMARY-PROGRESSIVE-APHASIA; POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL GLUCOSE-METABOLISM; HEXANUCLEOTIDE REPEAT EXPANSION; LOBAR DEGENERATION SPECTRUM; VOXEL-BASED MORPHOMETRY; WHITE-MATTER DAMAGE; PHF-TAU RADIOLIGAND; ALZHEIMERS-DISEASE; BEHAVIORAL VARIANT;

D O I：

10.1111/jnc.13640

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Frontotemporal dementia (FTD) is a common form of dementia with heterogeneous clinical presentations and distinct clinical syndromes. This article will review currently available therapies for FTD, its related disorders and their clinical evidence. It will also discuss recent advancements in FTD pathophysiology, treatment development, biomarker advancement and their relation to recently completed or currently ongoing clinical trials as well as future implications.

引用

页码：211 / 221

页数：11

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