Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model

被引：33
作者：
Fang, Wen [1 ]
Zhao, Shifang [2 ]
He, Fuming [2 ]
Liu, Li [3 ]
Yang, Guoli [2 ]
机构：
[1] Zhejiang Univ, Sch Med, Hangzhou 310000, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Stomatol Hosp, Dept Implantol, Hangzhou 310000, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Stomatol Hosp, Dept Prosthodont, Hangzhou 310000, Zhejiang, Peoples R China
来源：
BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷
基金：
中国国家自然科学基金;
关键词：
BONE-MINERAL DENSITY; DIFFERENTIATION; OSTEOGENESIS; INCREASES; FIXATION; STATINS;
D O I：
10.1155/2015/831504
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone. This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects of these simvastatin-HA coatings on implant surfaces in an animal model of osteoporosis. In this study, simvastatin-HA coated implants were inserted into the tibia of osteoporotic rats. After 2, 4, and 12 weeks, tissue was retrieved for histomorphometric evaluation. The results indicated that the simvastatin-HA coatings increased bone-implant contact and new bone formation around implant surfaces. In conclusion, implants loaded with simvastatin by an electrochemical process improved implant osseointegration in osteoporotic rats. Furthermore, the increased concentration of simvastatin could affect the osseointegration, but the dose-effects also need further investigation.
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