Impact of human leukocyte antigen mismatch on outcomes after unrelated bone marrow transplantation in paediatric patients: A retrospective analysis by the JS']JSTCT HLA working group

被引：1

作者：

Kato, Itaru ^{[1
]}

Sakaguchi, Hirotoshi ^{[2
]}

Kato, Shunichi ^{[3
]}

Sato, Maho ^{[4
]}

Noguchi, Maiko ^{[5
]}

Yoshida, Nao ^{[6
]}

Koh, Katsuyoshi ^{[7
]}

Koike, Takashi ^{[8
]}

Yanagimachi, Masakatsu ^{[9
]}

Kato, Keisuke ^{[10
]}

Takahashi, Yoshiyuki ^{[11
]}

Fujita, Naoto ^{[12
,13
]}

Sato, Atsushi ^{[14
]}

Hashii, Yoshiko ^{[15
]}

Tabuchi, Ken ^{[16
]}

Atsuta, Yoshiko ^{[17
,18
]}

Morishima, Satoko ^{[19
]}

Kanda, Junya ^{[20
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Pediat, Kyoto, Japan

[2] Natl Ctr Child Hlth & Dev, Children Canc Ctr, Tokyo, Japan

[3] Tokai Univ, Dept Innovat Med, Div Stem Cell Transplantat, Sch Med, Isehara, Kanagawa, Japan

[4] Osaka Womens & Childrens Hosp, Dept Hematol Oncol, Osaka, Japan

[5] Natl Hosp Org Kyushu Canc Ctr, Dept Pediat, Fukuoka, Japan

[6] Nagoya First Hosp, Childrens Med Ctr, Dept Hematol & Oncol, Japanese Red Cross Aichi Med Ctr, Nagoya, Aichi, Japan

[7] Saitama Childrens Med Ctr, Dept Hematol Oncol, Saitama, Japan

[8] Tokai Univ, Dept Pediat, Sch Med, Isehara, Kanagawa, Japan

[9] Kanagawa Childrens Med Ctr, Div Hematol Oncol, Yokohama, Kanagawa, Japan

[10] Ibaraki Childrens Hosp, Div Pediat Hematol & Oncol, Ibaraki, Japan

[11] Nagoya Univ, Dept Pediat, Grad Sch Med, Nagoya, Aichi, Japan

[12] Hiroshima Red Cross Hosp, Dept Pediat, Hiroshima, Japan

[13] Atom Bomb Survivors Hosp, Hiroshima, Japan

[14] Miyagi Childrens Hosp, Dept Hematol & Oncol, Sendai, Miyagi, Japan

[15] Osaka Int Canc Inst, Dept Pediat, Osaka, Japan

[16] Komagome Hosp, Div Pediat, Tokyo Metropolitan Govt, Bur Social Welf & Publ Hlth,Tokyo Metropolitan Ca, Tokyo, Japan

[17] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan

[18] Aichi Med Univ, Dept Registry Sci Transplant & Cellular Therapy, Sch Med, Nagakute, Aichi, Japan

[19] Univ Ryukyus, Grad Sch Med, Dept Internal Med 2, Div Endocrinol Diabet & Metab,Hematol,Rheumatol, Nishihara Cho, Nishihara, Okinawa, Japan

[20] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2022年 / 199卷 / 03期

关键词：

haematological malignancy; HLA mismatch; paediatrics; unrelated bone marrow transplantation; STEM-CELL TRANSPLANTATION; VERSUS-HOST-DISEASE; ALLELE MISMATCH; JAPAN SOCIETY; BLOOD; DIRECTION; LEUKEMIA;

D O I：

10.1111/bjh.18425

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The impact of human leukocyte antigen (HLA) mismatching at the HLA-A, -B, -C, and -DRB1 loci after unrelated bone marrow transplantation in paediatric patients with haematological malignancies has not been fully examined. Here, we analysed patients with haematological malignancies (all aged <= 15 years; n = 1330) who underwent a first unrelated bone marrow transplantation between 1993 and 2017 in Japan. The results show that although an HLA mismatch was significantly associated with a low relapse rate, it was also associated with higher non-relapse mortality. There was a significant association between HLA mismatch and low overall survival. Locus mismatch analysis revealed that, as in adults, an HLA-C mismatch had a significant negative impact on survival; however, in paediatric patients, an HLA-DRB1 mismatch did not have a negative impact, although these HLA mismatch effects are weakened in recent cases. Taken together, the results suggest that an HLA-matched donor should be the first candidate for paediatric patients; however, for patients without a matched sibling or matched unrelated donor, we can select an unrelated donor with a mismatch at HLA-DRB1 if available.

引用

页码：392 / 400

页数：9

共 22 条

[21] Allogeneic marrow stem-cell transplantation from human leukocyte antigen-identical siblings versus human leukocyte antigen-allelic-matched unrelated donors (10/10) in patients with standard-risk hematologic malignancy:: A prospective study from the French Society of Bone Marrow Transplantation and Cell Therapy
Yakoub-Agha, Ibrahim
Mesnil, Florence
Kuentz, Mathieu
Boiron, Jean Michel
Ifrah, Norbert
Milpied, Noel
Chehata, Sami
Esperou, Helene
Vernant, Jean-Paul
Michallet, Mauricette
Buzyn, Agnes
Gratecos, Nicole
Cahn, Jean Yves
Bourhis, Jean Henri
Chir, Zina
Raffoux, Colette
Socie, Gerard
Golmard, Jean Louis
Jouet, Jean-Pierre
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (36) : 5695 - 5702
[22] Impact of Human Leukocyte Antigen Allele Mismatch in Unrelated Bone Marrow Transplantation with Reduced-Intensity Conditioning Regimen
Yokoyama, Hisayuki
Kanda, Junya
Fuji, Shigeo
Kim, Sung-Won
Fukuda, Takahiro
Najima, Yuho
Ohno, Hitoshi
Uchida, Naoyuki
Ueda, Yasunori
Eto, Tetsuya
Iwato, Koji
Kobayashi, Hikaru
Ozawa, Yukiyasu
Kondo, Tadakazu
Ichinohe, Tatsuo
Atsuta, Yoshiko
Kanda, Yoshinobu
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (02) : 300 - 309

← 1 2 3 →