ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy

被引：142

作者：

El Costa, Hicham ^{[1
,2
]}

Gouilly, Jordi ^{[1
]}

Mansuy, Jean-Michel ^{[2
]}

Chen, Qian ^{[1
]}

Levy, Claude ^{[3
]}

Cartron, Geraldine ^{[4
]}

Veas, Francisco ^{[5
]}

Al-Daccak, Reem ^{[6
]}

Izopet, Jacques ^{[1
,2
]}

Jabrane-Ferrat, Nabila ^{[1
]}

机构：

[1] Univ Toulouse 3, CNRS UMR5282, CPTP, INSERM U1043, F-31024 Toulouse, France

[2] CHU Toulouse, IFB, Virol Lab, F-31059 Toulouse, France

[3] Clin Sarrus Teinturiers, Serv Gynecol Obstet, F-31300 Toulouse, France

[4] CHU Toulouse, Serv Gynecol Obstet, F-31059 Toulouse, France

[5] Univ Montpellier, Fac Pharm, IRD, UMR Minist Def, F-34094 Montpellier, France

[6] Univ Paris Diderot, INSERM UMRS976, Hop St Louis, F-75010 Paris, France

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

INFECTION; ROLES; BIRTH;

D O I：

10.1038/srep35296

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The outbreak of the Zika Virus (ZIKV) and its association with fetal abnormalities have raised worldwide concern. However, the cellular tropism and the mechanisms of ZIKV transmission to the fetus during early pregnancy are still largely unknown. Therefore, we ex vivo modeled the ZIKV transmission at the maternal-fetal interface using organ culture from first trimester pregnancy samples. Here, we provide evidence that ZIKV strain circulating in Brazil infects and damages tissue architecture of the maternal decidua basalis, the fetal placenta and umbilical cord. We also show that ZIKV replicates differentially in a wide range of maternal and fetal cells, including decidual fibroblasts and macrophages, trophoblasts, Hofbauer cells as well as umbilical cord mesenchymal stem cells. The striking cellular tropism of ZIKV and its cytopathic-induced tissue injury during the first trimester of pregnancy could provide an explanation for the irreversible congenital damages.

引用

页数：9

共 31 条

[1] Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection [J].

Bayer, Avraham ;

Lennemann, Nicholas J. ;

Ouyang, Yingshi ;

Bramley, John C. ;

Morosky, Stefanie ;

De Azeved Marques, Ernesto Torres, Jr. ;

Cherry, Sara ;

Sadovsky, Yoel ;

Coyne, Carolyn B. .

CELL HOST & MICROBE, 2016, 19 (05) :705-712

[2] Replication Vesicles are Load- and Choke-Points in the Hepatitis C Virus Lifecycle [J].

Binder, Marco ;

Sulaimanov, Nurgazy ;

Clausznitzer, Diana ;

Schulze, Manuel ;

Hueber, Christian M. ;

Lenz, Simon M. ;

Schloeder, Johannes P. ;

Trippler, Martin ;

Bartenschlager, Ralf ;

Lohmann, Volker ;

Kaderali, Lars .

PLOS PATHOGENS, 2013, 9 (08)

[3] Zika Virus Infection in Pregnant Women in Rio de Janeiro [J].

Brasil, P. ;

Pereira, J. P., Jr. ;

Moreira, M. E. ;

Ribeiro Nogueira, R. M. ;

Damasceno, L. ;

Wakimoto, M. ;

Rabello, R. S. ;

Valderramos, S. G. ;

Halai, U. -A. ;

Salles, T. S. ;

Zin, A. A. ;

Horovitz, D. ;

Daltro, P. ;

Boechat, M. ;

Gabaglia, C. Raja ;

Carvalho de Sequeira, P. ;

Pilotto, J. H. ;

Medialdea-Carrera, R. ;

Cotrim da Cunha, D. ;

Abreu de Carvalho, L. M. ;

Pone, M. ;

Machado Siqueira, A. ;

Calvet, G. A. ;

Rodrigues Baiao, A. E. ;

Neves, E. S. ;

Nassar de Carvalho, P. R. ;

Hasue, R. H. ;

Marschik, P. B. ;

Einspieler, C. ;

Janzen, C. ;

Cherry, J. D. ;

Bispo de Filippis, A. M. ;

Nielsen-Saines, K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (24) :2321-2334

[4] Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study [J].

Calvet, Guilherme ;

Aguiar, Renato S. ;

Melo, Adriana S. O. ;

Sampaio, Simone A. ;

de Filippis, Ivano ;

Fabri, Allison ;

Araujo, Eliane S. M. ;

de Sequeira, Patricia C. ;

de Mendonca, Marcos C. L. ;

de Oliveira, Louisi ;

Tschoeke, Diogo A. ;

Schrago, Carlos G. ;

Thompson, Fabiano L. ;

Brasil, Patricia ;

dos Santos, Flavia B. ;

Nogueira, Rita M. R. ;

Tanurit, Amilcar ;

de Filippis, Ana M. B. .

LANCET INFECTIOUS DISEASES, 2016, 16 (06) :653-660

[5] The Brazilian Zika virus strain causes birth defects in experimental models [J].

Cugola, Fernanda R. ;

Fernandes, Isabella R. ;

Russo, Fabiele B. ;

Freitas, Beatriz C. ;

Dias, Joao L. M. ;

Guimaraes, Katia P. ;

Benazzato, Cecilia ;

Almeida, Nathalia ;

Pignatari, Graciela C. ;

Romero, Sarah ;

Polonio, Carolina M. ;

Cunha, Isabela ;

Freitas, Carla L. ;

Brandao, Wesley N. ;

Rossato, Cristiano ;

Andrade, David G. ;

Faria, Daniele de P. ;

Garcez, Alexandre T. ;

Buchpigel, Carlos A. ;

Braconi, Carla T. ;

Mendes, Erica ;

Sall, Amadou A. ;

Zanotto, Paolo M. de A. ;

Peron, Jean Pierre S. ;

Muotri, Alysson R. ;

Beltrao-Braga, Patricia C. B. .

NATURE, 2016, 534 (7606) :267-+

[6] The local environment orchestrates mucosal decidual macrophage differentiation and substantially inhibits HIV-1 replication [J].

El Costa, H. ;

Quillay, H. ;

Marlin, R. ;

Cannou, C. ;

Duriez, M. ;

Benjelloun, F. ;

de Truchis, C. ;

Rahmati, M. ;

Ighil, J. ;

Barre-Sinoussi, F. ;

Nugeyre, M. T. ;

Menu, E. .

MUCOSAL IMMUNOLOGY, 2016, 9 (03) :634-646

[7] Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy [J].

El Costa, Hicham ;

Casemayou, Audrey ;

Aguerre-Girr, Maryse ;

Rabot, Magali ;

Berrebi, Alain ;

Parant, Olivier ;

Clouet-Delannoy, Muriel ;

Lombardelli, Letizia ;

Jabrane-Ferrat, Nabila ;

Rukavina, Daniel ;

Bensussan, Armand ;

Piccinni, Marie-Pierre ;

Le Bouteiller, Philippe ;

Tabiasco, Julie .

JOURNAL OF IMMUNOLOGY, 2008, 181 (05) :3009-3017

[8] Pathogenesis of Flavivirus Infections: Using and Abusing the Host Cell [J].

Fernandez-Garcia, Maria-Dolores ;

Mazzon, Michela ;

Jacobs, Michael ;

Amara, Ali .

CELL HOST & MICROBE, 2009, 5 (04) :318-328

[9] Biology of Zika Virus Infection in Human Skin Cells [J].

Hamel, Rodolphe ;

Dejarnac, Ophelie ;

Wichit, Sineewanlaya ;

Ekchariyawat, Peeraya ;

Neyret, Aymeric ;

Luplertlop, Natthanej ;

Perera-Lecoin, Manuel ;

Surasombatpattana, Pornapat ;

Talignani, Loic ;

Thomas, Frederic ;

Cao-Lormeau, Van-Mai ;

Choumet, Valerie ;

Briant, Laurence ;

Despres, Philippe ;

Amara, Ali ;

Yssel, Hans ;

Misse, Dorothee .

JOURNAL OF VIROLOGY, 2015, 89 (17) :8880-8896

[10] The up side of decidual natural killer cells: new developments in immunology of pregnancy [J].

Jabrane-Ferrat, Nabila ;

Siewiera, Johan .

IMMUNOLOGY, 2014, 141 (04) :490-497

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