Evasion of intracellular host defence by hepatitis C virus

被引：478
作者：
Gale, M [1 ]
Foy, EM [1 ]
机构：
[1] Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX 75390 USA
来源：
NATURE | 2005年 / 436卷 / 7053期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nature04078
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Viral infection of mammalian cells rapidly triggers intracellular signalling events leading to interferon alpha/beta production and a cellular antiviral state. This 'host response' is our first line of immune defence against infection as it imposes several barriers to viral replication and spread. Hepatitis C virus (HCV) evades the host response through a complex combination of processes that include signalling interference, effector modulation and continual viral genetic variation. These evasion strategies support persistent infection and the spread of HCV. Defining the molecular mechanisms by which HCV regulates the host response is of crucial importance and may reveal targets for novel therapeutic strategies.
引用
收藏
页码：939 / 945
页数：7
相关论文
共 94 条
  • [51] LIDENBACH BD, 2005, SCIENCE, V309, P623
  • [52] Lin RT, 1999, MOL CELL BIOL, V19, P959
  • [53] Hepatitis C virus NS5A: tales of a promiscuous protein
    Macdonald, A
    Harris, M
    [J]. JOURNAL OF GENERAL VIROLOGY, 2004, 85 : 2485 - 2502
  • [54] Induction and regulation of IFNs during viral infections
    Malmgaard, L
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2004, 24 (08) : 439 - 454
  • [55] Introduction of replication-competent hepatitis C virus transcripts using a tetracycline-regulable baculovirus delivery system
    McCormick, CJ
    Challinor, L
    Macdonald, A
    Rowlands, DJ
    Harris, M
    [J]. JOURNAL OF GENERAL VIROLOGY, 2004, 85 : 429 - 439
  • [56] McHutchison JG, 2004, AM J MANAG CARE, V10, pS21
  • [57] Future therapy of hepatitis C
    McHutchison, JG
    Patel, K
    [J]. HEPATOLOGY, 2002, 36 (05) : S245 - S252
  • [58] IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts
    McWhirter, SM
    Fitzgerald, KA
    Rosains, J
    Rowe, DC
    Golenbock, DT
    Maniatis, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) : 233 - 238
  • [59] Interferon type I gene expression in chronic hepatitis C
    Mihm, S
    Frese, M
    Meier, V
    Wietzke-Braun, P
    Scharf, JG
    Bartenschlager, R
    Ramadori, G
    [J]. LABORATORY INVESTIGATION, 2004, 84 (09) : 1148 - 1159
  • [60] Effects of mutation in hepatitis C virus nonstructural protein 5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells
    Noguchi, T
    Satoh, S
    Noshi, T
    Hatada, E
    Fukuda, R
    Kawai, A
    Ikeda, S
    Hijikata, M
    Shimotohno, K
    [J]. MICROBIOLOGY AND IMMUNOLOGY, 2001, 45 (12) : 829 - 840
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