Microstructural Alterations in Hippocampal Subfields Mediate Age-Related Memory Decline in Humans

被引:35
作者
Radhakrishnan, Hamsanandini [1 ]
Stark, Shauna M. [2 ]
Stark, Craig E. L. [1 ,2 ]
机构
[1] Univ Calif Irvine, Math Computat & Syst Biol, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA
来源
FRONTIERS IN AGING NEUROSCIENCE | 2020年 / 12卷
关键词
hippocampus; diffusion-weighted imaging; NODDI; fornix; aging; NEURITE ORIENTATION DISPERSION; WHITE-MATTER INTEGRITY; DIFFUSION MRI; EPISODIC MEMORY; FIBER DENSITY; FREE-WATER; BRAIN; MYELIN; NODDI; CONNECTIONS;
D O I
10.3389/fnagi.2020.00094
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Aging, even in the absence of clear pathology of dementia, is associated with cognitive decline. Neuroimaging, especially diffusion-weighted imaging, has been highly valuable in understanding some of these changes in live humans, non-invasively. Traditional tensor techniques have revealed that the integrity of the fornix and other white matter tracts significantly deteriorates with age, and that this deterioration is highly correlated with worsening cognitive performance. However, traditional tensor techniques are still not specific enough to indict explicit microstructural features that may be responsible for age-related cognitive decline and cannot be used to effectively study gray matter properties. Here, we sought to determine whether recent advances in diffusion-weighted imaging, including Neurite Orientation Dispersion and Density Imaging (NODDI) and Constrained Spherical Deconvolution, would provide more sensitive measures of age-related changes in the microstructure of the medial temporal lobe. We evaluated these measures in a group of young (ages 20-38 years old) and older (ages 59-84 years old) adults and assessed their relationships with performance on tests of cognition. We found that the fiber density (FD) of the fornix and the neurite density index (NDI) of the fornix, hippocampal subfields (DG/CA3, CA1, and subiculum), and parahippocampal cortex, varied as a function of age in a cross-sectional cohort. Moreover, in the fornix, DG/CA3, and CA1, these changes correlated with memory performance on the Rey Auditory Verbal Learning Test (RAVLT), even after regressing out the effect of age, suggesting that they were capturing neurobiological properties directly related to performance in this task. These measures provide more details regarding age-related neurobiological properties. For example, a change in fiber density could mean a reduction in axonal packing density or myelination, and the increase in NDI observed might be explained by changes in dendritic complexity or even sprouting. These results provide a far more comprehensive view than previously determined on the possible system-wide processes that may be occurring because of healthy aging and demonstrate that advanced diffusion-weighted imaging is evolving into a powerful tool to study more than just white matter properties.
引用
收藏
页数:15
相关论文
共 96 条
  • [51] USE OF REDUCED SILVER STAINING TO SHOW LOSS OF CONNECTIONS IN AGED RAT-BRAIN
    NARANJO, N
    GREENE, E
    [J]. BRAIN RESEARCH BULLETIN, 1977, 2 (01) : 71 - 74
  • [52] Functional Consequences of Neurite Orientation Dispersion and Density in Humans across the Adult Lifespan
    Nazeri, Arash
    Chakravarty, M. Mallar
    Rotenberg, David J.
    Rajji, Tarek K.
    Rathi, Yogesh
    Michailovich, Oleg V.
    Voineskos, Aristotle N.
    [J]. JOURNAL OF NEUROSCIENCE, 2015, 35 (04) : 1753 - 1762
  • [53] Nonparametric permutation tests for functional neuroimaging: A primer with examples
    Nichols, TE
    Holmes, AP
    [J]. HUMAN BRAIN MAPPING, 2002, 15 (01) : 1 - 25
  • [54] Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study
    Ofori, Edward
    Pasternak, Ofer
    Planetta, Peggy J.
    Burciu, Roxana
    Snyder, Amy
    Febo, Marcelo
    Golde, Todd E.
    Okun, Michael S.
    Vaillancourt, David E.
    [J]. NEUROBIOLOGY OF AGING, 2015, 36 (02) : 1097 - 1104
  • [55] Fixel-based analysis reveals alterations is brain microstructure and macrostructure of preterm-born infants at term equivalent age
    Pannek, Kerstin
    Fripp, Jurgen
    George, Joanne M.
    Fiori, Simona
    Colditz, Paul B.
    Boyd, Roslyn N.
    Rose, Stephen E.
    [J]. NEUROIMAGE-CLINICAL, 2018, 18 : 51 - 59
  • [56] Free Water Elimination and Mapping from Diffusion MRI
    Pasternak, Ofer
    Sochen, Nir
    Gur, Yaniv
    Intrator, Nathan
    Assaf, Yaniv
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2009, 62 (03) : 717 - 730
  • [57] The effects of normal aging on myelin and nerve fibers: A review
    Peters, A
    [J]. JOURNAL OF NEUROCYTOLOGY, 2002, 31 (8-9): : 581 - 593
  • [58] How the Primate Fornix Is Affected by Age
    Peters, Alan
    Sethares, Claire
    Moss, Mark B.
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2010, 518 (19) : 3962 - 3980
  • [59] Communication breakdown: The impact of ageing on synapse structure
    Petralia, Ronald S.
    Mattson, Mark P.
    Yao, Pamela J.
    [J]. AGEING RESEARCH REVIEWS, 2014, 14 : 31 - 42
  • [60] PROCESS macro for SPSS and SAS, 2019, PROCESS MACR SPSS SA