Synthetic and Reactions Routes to Tetrahydrothieno[3,2-b]Quinoline Derivatives (Part IV)

被引：23

作者：

Abu-Hashem, Ameen A. ^{[1
,2
]}

Abdelgawad, Ahmed A. M. ^{[2
,3
]}

Hussein, Hoda A. R. ^{[1
]}

Gouda, Moustafa A. ^{[4
,5
]}

机构：

[1] Natl Res Ctr, Heterocycl Unit, Photochem Dept, Giza 12622, Egypt

[2] Jazan Univ, Fac Sci, Chem Dept, Jazan 45142, Saudi Arabia

[3] Desert Res Ctr, Med & Aromat Plants Dept, Cairo, Egypt

[4] Taibah Univ, Fac Sci & Arts, Dept Chem, Medina, Saudi Arabia

[5] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2022年 / 19卷 / 01期

关键词：

Pyridine-3-carbonitrile; pyrimidine-5-carbonitrile; 3-aminothiophene-2-carbonitrile; iodoisoquinolines; mercapto-benzoquinolinones; synthesis; reactivity; CONVENIENT SYNTHESIS; FACILE SYNTHESIS; ANALOGS; PYRIMIDINE; EFFICIENT; PYRAZOLE; DESIGN; PYRIDO; SERIES;

D O I：

10.2174/1570193X18666210218212719

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review describes the synthesis and chemical reactivity of tetrahydrothieno[3,2-b] quinoline derivatives through many reagents such as; 1, 2-dihydropyridine-3-carbonitrile; 1,6-dihydropyrimidine-5-carbonitrile; 2,3-dihydropyridazine-4-carbonitrile; 3-amino-thiophene-2-carboxylate; 3amino-thiophene-2-carbonitrile; 3,4-diaminothieno[2,3-b] thiophene-2,5-dicarbo-nitrile; 2-(3-bromo-1iodoisoquinolin-8-yl) benzonitrile and 3-mercapto-benzo[g]quinolin-4(1H)-one derivatives. The synthesis of tetrahydrothieno [3, 2-b] quinoline derivatives was explained through the following chemical reactions: Aldol condensation, alkylation, cyclocondensation, dehydration, chlorination, Wolff-Kishner reduction, acylation, Friedlander reaction and intramolecular cyclization.

引用

页码：74 / 91

页数：18

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