Plasma Platelet-derived Microparticles in Patients with Connective Tissue Diseases

被引：19

作者：

Oyabu, Chinami ^{[1
]}

Morinobu, Akio ^{[1
]}

Sugiyama, Daisuke ^{[1
]}

Saegusa, Jun ^{[1
]}

Tanaka, Shino ^{[1
]}

Morinobu, Sahoko ^{[1
]}

Tsuji, Goh ^{[1
]}

Kasagi, Shimpei ^{[1
]}

Kawano, Seiji ^{[1
]}

Kumagai, Shunichi ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Clin Pathol & Thummol, Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

JOURNAL OF RHEUMATOLOGY | 2011年 / 38卷 / 04期

关键词：

RAYNAUD'S PHENOMENON; MICROPARTICLE; PLATELET; CONNECTIVE TISSUE DISEASES; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; APOPTOTIC CELLS; SCLEROSIS; CLASSIFICATION; PATHOGENESIS; INFLAMMATION; ACTIVATION;

D O I：

10.3899/jrheum.100780

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To clarify the role of platelet-derived microparticles (PDMP), which are small vesicles with thrombotic and immunological properties, in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis/polymyositis (PM/DM), and mixed connective tissue disease (MCTD). Methods. Plasma levels of PDMP were measured by ELISA, and compared among patients with one of the 4 diseases. Association of PDMP levels with clinical characteristics and medication of the patients was also examined. Results. PDMP levels were higher in patients with MCTD and SSc than in controls. Multiple linear regression analysis revealed that patients with Raynaud's phenomenon (RP) showed higher PDMP levels than those without. PDMP levels in individual patients did not fluctuate significantly over several months. Conclusion. PDMP level is associated with MCTD, SSc, and RP, and could be a novel marker for RP. (First Release Jan 15 2011; J Rheumatol 2011;38:680-4; doi:10.3899/jrheum.100780)

引用

页码：680 / 684

页数：5

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