Electrochemical Cobalt-Catalyzed C-H Oxygenation at Room Temperature

被引：274

作者：

Sauermann, Nicolas ^{[1
]}

Meyer, Tjark H. ^{[1
]}

Tian, Cong ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 51期

关键词：

CROSS-COUPLING REACTIONS; CARBON-HYDROGEN; MECHANISTIC INSIGHTS; BOND FORMATION; PALLADIUM; FUNCTIONALIZATION; METAL; OXIDATION; ARYLATION; ACTIVATION;

D O I：

10.1021/jacs.7b11025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electrochemical cobalt-catalyzed C-H functionalizations were achieved in terms of C-H oxygenation under mild conditions at 23 degrees C. The robust electrochemical C-H functionalization was characterized by ample substrate scope, whereas mechanistic studies provided support for a facile C-H cleavage. The electrochemical cobalt-catalyzed C-H oxygenation proved viable on arenes and alkenes with excellent levels of positional and diastereo-selectivity, avoiding the use of stoichiometric silver(I) oxidants under ambient conditions.

引用

页码：18452 / 18455

页数：4

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