Effects of Aqueous Peat Extract on the Activity of Cyclooxygenase and Cyclooxygenase-1 and Cyclooxygenase-2 Isoforms

被引：5
作者：
Beer, A. M. [1 ]
Zagorchev, P. [2 ]
Filipova, M. [2 ]
Lukanov, J. [2 ]
机构：
[1] Klin Nat Heilkunde, D-45527 Hattingen, Germany
[2] DBSc Med Univ, Biophys Dept, Plovdiv, Bulgaria
来源：
PHYSIKALISCHE MEDIZIN REHABILITATIONSMEDIZIN KURORTMEDIZIN | 2015年 / 25卷 / 01期
关键词：
peat; aqueous peat extract; inflammation; Indometacin; cyclooxygenase;
D O I：
10.1055/s-0034-1396796
中图分类号：
R49 [康复医学];
学科分类号：
100215 ;
摘要：
Purpose: The anti-inflammatory effects of peat in the treatment of rheumatic diseases are observed in clinical use for some time. So far it is not clear resulted from the peat research why a peat healing bath includes anti-inflammatory effects. The thermal effects itself cannot explain these effects. Material and methods: Therefore the effect of aqueous peat extract (WTE) on the activity of cyclooxygenase and its 2 isoforms COX-1 and COX-2 were analyzed and compared with Indometacin. Results: The ratio between the concentrations required to reach a suppression of 50 % of the activities of COX-1 and COX-2 isoforms amounts to 1.79. Discussion: For Indometacin the ratio is 0.17. So it is about 10 times less than that of WTE. Conclusions: The results of the present studies provide useful data to classify the aqueous peat extract as a specific COX-2 blockers.
引用
收藏
页码：51 / 54
页数：4
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