Preparation and properties of PEG modified PNVP hydrogel

被引：10

作者：

Son, Young Kyo

Kim, Ji-Heung ^{[1
]}

Jeon, Young Sill

Chung, Dong June

机构：

[1] Sungkyunkwan Univ, Polymer Technol Inst, Suwon 440746, South Korea

[2] Sungkyunkwan Univ, Dept Chem Engn, Suwon 440746, South Korea

[3] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Suwon 440746, South Korea

来源：

MACROMOLECULAR RESEARCH | 2007年 / 15卷 / 06期

关键词：

polymeric hydrogel; PNVP; PEG; biocompatibility;

D O I：

10.1007/BF03218826

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polymer hydrogel has attracted considerable interest as a soft material which is finding expanding applications in pharmaceutics and various biomedical fields. In this work, modified PNVP hydrogels were synthesized by crosslinking polymerization of NVP monomer in the presence of PEG macromer with a methoxy end. The effect of the tethered PEG chain on the properties of the hydrogel was investigated in terms of its swelling capacity, compression gel strength, and the morphology of the resulting hydrogels. These PEG-modified PNVP hydrogels possessed good biocompatibility and a decreased protein (fibrinogen) adsorption, thereby indicating their potential as novel drug delivery matrices and scaffold for tissue engineering.

引用

收藏

页码：527 / 532

页数：6

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