Disaccharide nucleosides and their enzymatic and chemical incorporation into oligonucleotides

被引:7
作者
Efimtseva, EV
Victorova, LS
Rodionov, AA
Ermolinsky, BS
Fomitcheva, MV
Tunitskaya, VL
Mikhailov, SN
Oivanen, M
Van Aerschot, A
Herdewijn, P
机构
[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 117984, Russia
[2] Univ Turku, Dept Chem, FIN-20014 Turku, Finland
[3] Katholieke Univ Leuven, Rega Inst, B-3000 Louvain, Belgium
关键词
D O I
10.1080/07328319808004701
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A high yield synthesis of different O-ribofuranosylnucleosides has been achieved. Kinetics of the acid-catalysed hydrolysis of disaccharide nucleosides has been studied. Chemical and enzymatic incorporation of 2'-O-ribofuranosylnucleoside residue into oligonucleotides was investigated.
引用
收藏
页码:1681 / 1684
页数:4
相关论文
共 9 条
  • [1] Efimtseva EV, 1996, COLLECT CZECH CHEM C, V61, pS206
  • [2] MUTANTS OF T7 RNA-POLYMERASE THAT ARE ABLE TO SYNTHESIZE BOTH RNA AND DNA
    KOSTYUK, DA
    DRAGAN, SM
    LYAKHOV, DL
    RECHINSKY, VO
    TUNITSKAYA, VL
    CHERNOV, BK
    KOCHETKOV, SN
    [J]. FEBS LETTERS, 1995, 369 (2-3) : 165 - 168
  • [3] LERNER LM, 1990, CHEM NUCLEOSIDES NUC, V2, P27
  • [4] THE MODIFIED NUCLEOSIDES OF RNA - SUMMARY
    LIMBACH, PA
    CRAIN, PF
    MCCLOSKEY, JA
    [J]. NUCLEIC ACIDS RESEARCH, 1994, 22 (12) : 2183 - 2196
  • [5] An efficient synthesis and physico-chemical properties of 2'-O-D-ribofuranosylnucleosides, minor tRNA components
    Mikhailov, SN
    Efimtseva, EV
    Gurskaya, GV
    Fomitcheva, MV
    Meshkov, SV
    Zavodnik, VE
    DeBruyn, A
    Janssen, G
    Rozenski, J
    Herdewijn, P
    [J]. JOURNAL OF CARBOHYDRATE CHEMISTRY, 1997, 16 (01) : 75 - 92
  • [6] SYNTHESIS AND PROPERTIES OF SOME 2'-O-D-RIBOFURANOSYL-NUCLEOSIDES
    MIKHAILOV, SN
    DEBRUYN, A
    HERDEWIJN, P
    [J]. NUCLEOSIDES & NUCLEOTIDES, 1995, 14 (3-5): : 481 - 484
  • [7] Ribosylation of pyrimidine 2'-deoxynucleosides
    Mikhailov, SN
    DeClercq, E
    Herdewijn, P
    [J]. NUCLEOSIDES & NUCLEOTIDES, 1996, 15 (7-8): : 1323 - 1334
  • [8] MIKHAILOV SN, IN PRESS CARBOHYDR L
  • [9] STUDIES ON THE SYNTHESIS OF O-RIBOSYL-ADENOSINE - A NEW MINOR NUCLEOSIDE OF TRANSFER-RNA
    NIEWCZYK, A
    KRZYZANIAK, A
    BARCISZEWSKI, J
    MARKIEWICZ, WT
    [J]. NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (1-3): : 635 - 638