Advances in COVID-19 Vaccines and New Coronavirus Variants

被引:4
作者
Liu, Mengchen [1 ]
Li, Yunqiao [1 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Geriatr, Wuhan, Peoples R China
关键词
COVID-19; SARS-CoV-2; variant; omicron; vaccine; effectiveness; SARS-COV-2; VARIANTS; OMICRON VARIANT; BNT162B2; SAFETY; RISK;
D O I
10.3389/fmed.2022.888631
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
With the successful development of the Corona Virus Disease 2019 (COVID-19) vaccines and increased vaccination coverage, great progress in global outbreak control has been made in several countries. However, new coronavirus variants emerge and their rapid spread, causing a new wave of economic and social upheaval worldwide. The spread of new coronavirus variants poses a new and enormous challenge to vaccination and pandemic control, so further studies to explore and develop vaccines for the prevention and control virus infection are warranted. In this review, we provide an overview of the most prevalent variants including Omicron, and explore the effectiveness of COVID-19 vaccines against related variants to better understand existing vaccines and to facilitate improved research into new vaccines. In addition, this review discusses existing strategies to increase vaccine efficacy and introduces novel vaccines by the non-injection route.
引用
收藏
页数:10
相关论文
共 77 条
[1]   Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants [J].
Abu-Raddad, Laith J. ;
Chemaitelly, Hiam ;
Butt, Adeel A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (02) :187-189
[2]   Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost [J].
Ai, Jingwen ;
Zhang, Haocheng ;
Zhang, Yi ;
Lin, Ke ;
Zhang, Yanliang ;
Wu, Jing ;
Wan, Yanming ;
Huang, Yanfang ;
Song, Jieyu ;
Fu, Zhangfan ;
Wang, Hongyu ;
Guo, Jingxin ;
Jiang, Ning ;
Fan, Mingxiang ;
Zhou, Yang ;
Zhao, Yuanhan ;
Zhang, Qiran ;
Liu, Qiang ;
Lv, Jing ;
Li, Peiyao ;
Qiu, Chao ;
Zhang, Wenhong .
EMERGING MICROBES & INFECTIONS, 2022, 11 (01) :337-343
[3]   Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses [J].
Alameh, Mohamad-Gabriel ;
Tombacz, Istvan ;
Bettini, Emily ;
Lederer, Katlyn ;
Sittplangkoon, Chutamath ;
Wilmore, Joel R. ;
Gaudette, Brian T. ;
Soliman, Ousamah Y. ;
Pine, Matthew ;
Hicks, Philip ;
Manzoni, Tomaz B. ;
Knox, James J. ;
Johnson, John L. ;
Laczko, Dorottya ;
Muramatsu, Hiromi ;
Davis, Benjamin ;
Meng, Wenzhao ;
Rosenfeld, Aaron M. ;
Strohmeier, Shirin ;
Lin, Paulo J. C. ;
Mui, Barbara L. ;
Tam, Ying K. ;
Kariko, Katalin ;
Jacquet, Alain ;
Krammer, Florian ;
Bates, Paul ;
Cancro, Michael P. ;
Weissman, Drew ;
Prak, Eline T. Luning ;
Allman, David ;
Locci, Michela ;
Pardi, Norbert .
IMMUNITY, 2021, 54 (12) :2877-+
[4]  
Aleem A, 2022, Emerging Variants of SARS-CoV-2 and Novel Therapeutics Against Coronavirus (COVID-19)
[5]   Algeria's preparedness for Omicron variant and for the fourth wave of COVID-19 [J].
Aouissi, Hani Amir .
GLOBAL HEALTH & MEDICINE, 2021, 3 (06) :413-414
[6]   BNT162b2 Vaccine Booster and Mortality Due to Covid-19 [J].
Arbel, Ronen ;
Hammerman, Ariel ;
Sergienko, Ruslan ;
Friger, Michael ;
Peretz, Alon ;
Netzer, Doron ;
Yaron, Shlomit .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (26) :2413-2420
[7]   Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting [J].
Barda, Noam ;
Dagan, Noa ;
Ben-Shlomo, Yatir ;
Kepten, Eldad ;
Waxman, Jacob ;
Ohana, Reut ;
Hernan, Miguel A. ;
Lipsitch, Marc ;
Kohane, Isaac ;
Netzer, Doron ;
Reis, Ben Y. ;
Balicer, Ran D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (12) :1078-1090
[8]   Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination [J].
Barros-Martins, Joana ;
Hammerschmidt, Swantje, I ;
Cossmann, Anne ;
Odak, Ivan ;
Stankov, Metodi, V ;
Ramos, Gema Morillas ;
Dopfer-Jablonka, Alexandra ;
Heidemann, Annika ;
Ritter, Christiane ;
Friedrichsen, Michaela ;
Schultze-Florey, Christian ;
Ravens, Inga ;
Willenzon, Stefanie ;
Bubke, Anja ;
Ristenpart, Jasmin ;
Janssen, Anika ;
Ssebyatika, George ;
Bernhardt, Gunter ;
Muench, Jan ;
Hoffmann, Markus ;
Poehlmann, Stefan ;
Krey, Thomas ;
Bosnjak, Berislav ;
Foerster, Reinhold ;
Behrens, Georg M. N. .
NATURE MEDICINE, 2021, 27 (09) :1525-+
[9]   Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients [J].
Bernal, A. Jayk ;
da Silva, M. M. Gomes ;
Musungaie, D. B. ;
Kovalchuk, E. ;
Gonzalez, A. ;
Delos Reyes, V ;
Martin-Quiros, A. ;
Caraco, Y. ;
Williams-Diaz, A. ;
Brown, M. L. ;
Du, J. ;
Pedley, A. ;
Assaid, C. ;
Strizki, J. ;
Grobler, J. A. ;
Shamsuddin, H. H. ;
Tipping, R. ;
Wan, H. ;
Paschke, A. ;
Butterton, J. R. ;
Johnson, M. G. ;
De Anda, C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (06) :509-520
[10]   Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant [J].
Bernal, Jamie Lopez ;
Andrews, Nick ;
Gower, Charlotte ;
Gallagher, Eileen ;
Simmons, Ruth ;
Thelwall, Simon ;
Stowe, Julia ;
Tessier, Elise ;
Groves, Natalie ;
Dabrera, Gavin ;
Myers, Richard ;
Campbell, Colin N. J. ;
Amirthalingam, Gayatri ;
Edmunds, Matt ;
Zambon, Maria ;
Brown, Kevin E. ;
Hopkins, Susan ;
Chand, Meera ;
Ramsay, Mary .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (07) :585-594