Structure and cytotoxicity of biodegradable poly(D,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin

被引：15

作者：

Razuvaeva, Ekaterina, V ^{[1
]}

Kalinin, Kirill T. ^{[1
]}

Sedush, Nikita G. ^{[1
]}

Nazarov, Alexey A. ^{[2
]}

Volkov, Dmitry S. ^{[2
]}

Chvalun, Sergei N. ^{[1
,3
]}

机构：

[1] Natl Res Ctr Kurchatov Inst, Moscow 123182, Russia

[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

[3] Russian Acad Sci, NS Enikolopov Inst Synthet Polymer Mat, Moscow 117393, Russia

来源：

MENDELEEV COMMUNICATIONS | 2021年 / 31卷 / 04期

基金：

俄罗斯科学基金会;

关键词：

lactide; glycolide; poly(lactide-co-glycolide); nanoparticles; oxaliplatin; drug delivery system; PLGA NANOPARTICLES; PARTICLE-SIZE; DELIVERY; DEGRADATION; DRUGS;

D O I：

10.1016/j.mencom.2021.07.025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Spherical nanoparticles based on the biocompatible and biodegradable poly(D,l-lactide-co-glycolide) copolymer (90 : 10) loaded with oxaliplatin were produced by nanoprecipitation. Effect of the oxaliplatin loading on structure, size and morphology of the copolymer particles is considered. The nanoformulation of oxaliplatin demonstrates enhanced cytotoxicity and selectivity in vitro against several cancer cells compared with the free drug.

引用

页码：512 / 514

页数：3

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