Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia

被引：282
作者：
Lurain, John R. [1 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, John I Brewer Trophoblast Dis Ctr, Chicago, IL 60611 USA
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2011年 / 204卷 / 01期
关键词：
chemotherapy; choriocarcinoma; gestational trophoblastic disease; gestational trophoblastic neoplasia; WEEKLY INTRAMUSCULAR METHOTREXATE; SINGLE-AGENT METHOTREXATE; LOW-DOSE METHOTREXATE; ACTINOMYCIN-D; FOLINIC ACID; PRIMARY THERAPY; VINCRISTINE CHEMOTHERAPY; PREGNANCY OUTCOMES; PULSE METHOTREXATE; EMA/CO ETOPOSIDE;
D O I：
10.1016/j.ajog.2010.06.072
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Gestational trophoblastic neoplasia (GTN) includes invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The overall cure rate in treating these tumors is currently >90%. Thorough evaluation and staging allow selection of appropriate therapy that maximizes chances for cure while minimizing toxicity. Nonmetastatic (stage I) and low-risk metastatic (stages II and III, score <7) GTN can be treated with single-agent chemotherapy resulting in a survival rate approaching 100%. High-risk GTN (stages II-IV, score >= 7) requires initial multiagent chemotherapy with or without adjuvant radiation and surgery to achieve a survival rate of 80-90%.
引用
收藏
页码：11 / 18
页数：8
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