Synthesis of peptide-diazeniumdiolate conjugates: towards enzyme activated antitumor agents

被引：39

作者：

Tang, XP

Xian, M

Trikha, M

Honn, KV

Wang, PG ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Wayne State Univ, Dept Radiat Oncol & Pathol, Detroit, MI 48202 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 14期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(01)00263-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of NO donors with site-specific and time-controlled properties is of great interest. We have designed a novel prodrug class as possible agents against metastatic prostate cancer by coupling a diazeniumdiolate to the terminal carboxyl groups of amino acids or peptides, such as Ser-Ser-Tyr-Tyr, Ser-Ser-Phe-Tyr, and Gly-Ile-Ser-Ser-Phe-Tyr. These prodrugs can be activated by alpha -chymotrypsin or prostate specific antigen and are potentially potent compounds for prostatic cancer. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：2625 / 2629

页数：5

共 35 条

[1] Molecular forms of serum prostate-specific antigen - The clinical value of percent free prostate-specific antigen [J].