Hedgehog and adipogenesis: Fat and fiction

被引：50

作者：

Cousin, Wendy ^{[1
]}

Fontaine, Coralie ^{[1
]}

Dani, Christian ^{[1
]}

Peraldi, Pascal ^{[1
]}

机构：

[1] Univ Nice, CNRS, ISBDC, F-06100 Nice, France

来源：

BIOCHIMIE | 2007年 / 89卷 / 12期

关键词：

Hedgehog signaling pathway; Glil; Ihh; adipocyte differentiation; fat mass; obesity; lipodystrophy;

D O I：

10.1016/j.biochi.2007.08.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Morphogenes, abundantly described during embryogenesis have recently emerged as crucial modulators of cell differentiation processes. Hedgehog signaling, the dysregulation of which causing several pathologies such as congenital defects and cancer, is involved in several cell differentiation processes including adipogenesis. This review presents an overview of the relations between Hedgehog signaling, adipocyte differentiation and fat mass. While the anti-adipogenic role of Hedgehog signaling seems to be established, the effect of Hedgehog inhibition on adipocyte differentiation in vitro remains debated. Finally, Hedgehog potential as a pharmacological target to treat fat mass disorders is discussed. (C) 2007 Elsevier Masson SAS. All rights reserved.

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收藏

页码：1447 / 1453

页数：7

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