Structure-function relationships in polymeric multilayer capsules designed for cancer drug delivery

被引：11

作者：

Nifontova, Galina ^{[1
]}

Tsoi, Tatiana ^{[2
]}

Karaulov, Alexander ^{[3
]}

Nabiev, Igor ^{[1
,2
,3
]}

Sukhanova, Alyona ^{[1
]}

机构：

[1] Univ Reims, Lab Rech Nanosci, LRN EA4682, F-51100 Reims, France

[2] Natl Res Nucl Univ MEPhI, Moscow Engn Phys Inst, Moscow 115409, Russia

[3] Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow 119146, Russia

来源：

BIOMATERIALS SCIENCE | 2022年 / 10卷 / 18期

基金：

俄罗斯科学基金会;

关键词：

IN-VITRO; TARGETED DELIVERY; SINGLE-DOMAIN; POLYELECTROLYTE MICROCAPSULES; BIOCONJUGATION REACTIONS; SILICA NANOPARTICLES; PARTICLES; CELLS; SHAPE; SIZE;

D O I：

10.1039/d2bm00829g

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The targeted delivery of cancer drugs to tumor-specific molecular targets represents a major challenge in modern personalized cancer medicine. Engineering of micron and submicron polymeric multilayer capsules allows the obtaining of multifunctional theranostic systems serving as controllable stimulus-responsive tools with a high clinical potential to be used in cancer therapy and detection. The functionalities of such theranostic systems are determined by the design and structural properties of the capsules. This review (1) describes the current issues in designing cancer cell-targeting polymeric multilayer capsules, (2) analyzes the effects of the interactions of the capsules with the cellular and molecular constituents of biological fluids, and (3) presents the key structural parameters determining the effectiveness of capsule targeting. The influence of the morphological and physicochemical parameters and the origin of the structural components and surface ligands on the functional activity of polymeric multilayer capsules at the molecular, cellular, and whole-body levels are summarized. The basic structural and functional principles determining the future trends of theranostic capsule development are established and discussed.

引用

页码：5092 / 5115

页数：24

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