The PTX family of homeodomain transcription factors during pituitary developments

被引：89

作者：

Drouin, J ^{[1
]}

Lamolet, B ^{[1
]}

Lamonerie, T ^{[1
]}

Lanctôt, C ^{[1
]}

Tremblay, JJ ^{[1
]}

机构：

[1] Inst Rech Clin Montreal, Genet Mol Lab, Montreal, PQ H2W 1R7, Canada

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1998年 / 140卷 / 1-2期

关键词：

homeobox; pituitary; pro-opiomelanocortin; transcript ion factor;

D O I：

10.1016/S0303-7207(98)00026-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A subfamily of bicoid-related homeodomain factors was recently discovered through its involvement in transcription of pituitary-specific genes. We isolated the first member of this family, Ptx1 (pituitary homeobox 1), through its DNA binding properties whereas a second related gene, Ptx2 (RIEG), was identified by positional cloning as the causative gene for Rieger's syndrome. The mechanisms of Ptx action on its target genes as well as its putative roles during development are reviewed with particular emphasis on its role in pituitary function. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：31 / 36

页数：6

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