Dibenzofuran, 4-Chromanone, Acetophenone, and Dithiecine Derivatives: Cytotoxic Constituents from Eupatorium fortunei

被引：8

作者：

Chang, Chun-Hao ^{[1
]}

Wu, Semon ^{[2
]}

Hsu, Kai-Cheng ^{[3
,4
]}

Huang, Wei-Jan ^{[5
,6
]}

Chen, Jih-Jung ^{[7
,8
,9
]}

机构：

[1] Natl Yang Ming Chiao Tung Univ, Sch Pharmaceut Sci, Inst Biopharmaceut Sci, Taipei 112, Taiwan

[2] Chinese Culture Univ, Dept Life Sci, Taipei 110, Taiwan

[3] Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery, Taipei 110, Taiwan

[4] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Canc Mol Biol & Drug Discovery, Taipei 110, Taiwan

[5] Taipei Med Univ, Coll Pharm, PhD Program Biotechnol Res & Dev, Taipei 110, Taiwan

[6] Taipei Med Univ, Coll Pharm, Grad Inst Pharmacognosy, Taipei 110, Taiwan

[7] Natl Yang Ming Chiao Tung Univ, Sch Pharmaceut Sci, Dept Pharm, Taipei 112, Taiwan

[8] Natl Yang Ming Univ, Fac Pharm, Taipei 112, Taiwan

[9] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 14期

关键词：

Eupatorium fortunei; dibenzofuran; cytotoxity; apoptosis; THYMOL DERIVATIVES; PYRROLIZIDINE ALKALOIDS; DISCOVERY; APOPTOSIS;

D O I：

10.3390/ijms22147448

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new compounds, eupatodibenzofuran A (1), eupatodibenzofuran B (2), 6-acetyl-8-methoxy-2,2-dimethylchroman-4-one (3), eupatofortunone (4), and eupatodithiecine (5), have been isolated from the aerial part of Eupatorium fortunei, together with 11 known compounds (6-16). Compounds 1 and 2 featured a new carbon skeleton with an unprecedented 1-(9-(4-methylphenyl)-6-methyldibe nzo[b,d]furan-2-yl)ethenone. Among the isolates, compound 1 exhibited potent inhibitory activity with IC50 values of 5.95 +/- 0.89 and 5.55 +/- 0.23 mu M, respectively, against A549 and MCF-7 cells. The colony-formation assay demonstrated that compound 1 (5 mu M) obviously decreased A549 and MCF-7 cell proliferation, and Western blot test confirmed that compound 1 markedly induced apoptosis of A549 and MCF-7 cells through mitochondrial- and caspase-3-dependent pathways.

引用

页数：16

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