Towards an integrative view of virus phenotypes

被引：20

作者：

DeLong, John P. ^{[1
]}

Al-Sammak, Maitham A. ^{[2
,3
]}

Al-Ameeli, Zeina T. ^{[2
,3
,4
]}

Dunigan, David D. ^{[2
,3
,5
]}

Edwards, Kyle F. ^{[6
]}

Fuhrmann, Jeffry J. ^{[7
,8
]}

Gleghorn, Jason P. ^{[8
,9
]}

Li, Hanqun ^{[8
,10
]}

Haramoto, Kona ^{[7
,10
]}

Harrison, Amelia O. ^{[7
,10
]}

Marston, Marcia F. ^{[11
]}

Moore, Ryan M. ^{[10
,12
]}

Polson, Shawn W. ^{[7
,8
,10
,12
]}

Ferrell, Barbra D. ^{[10
,12
]}

Salsbery, Miranda E. ^{[1
]}

Schvarcz, Christopher R. ^{[6
]}

Shirazi, Jasmine ^{[9
]}

Steward, Grieg F. ^{[6
]}

Van Etten, James L. ^{[3
,5
]}

Wommack, K. Eric ^{[7
,8
,10
]}

机构：

[1] Univ Nebraska Lincoln, Sch Biol Sci, Lincoln, NE 68588 USA

[2] Univ Baghdad, Coll Sci, Trop Biol Res Unit, Baghdad, Iraq

[3] Univ Nebraska Lincoln, Nebraska Ctr Virol, Lincoln, NE USA

[4] Middle Tech Univ, Med Tech Inst, Baghdad, Iraq

[5] Univ Nebraska Lincoln, Dept Plant Pathol, Lincoln, NE USA

[6] Univ Hawaii Manoa, Dept Oceanog, Honolulu, HI 96822 USA

[7] Univ Delaware, Dept Plant & Soil Sci, Newark, DE 19716 USA

[8] Univ Delaware, Dept Biol Sci, Newark, DE 19716 USA

[9] Univ Delaware, Dept Biomed Engn, Newark, DE USA

[10] Univ Delaware, Delaware Biotechnol Inst, Newark, DE 19716 USA

[11] Roger Williams Univ, Dept Biol & Marine Biol, Bristol, RI 02809 USA

[12] Univ Delaware, Ctr Bioinformat & Computat Biol, Newark, DE USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2022年 / 20卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

MARINE VIRUSES; PHOTOSYNTHESIS GENES; PARAMECIUM-BURSARIA; PHAGE INFECTION; ARMS-RACE; EVOLUTION; HOST; TEMPERATURE; PLASTICITY; DIVERSITY;

D O I：

10.1038/s41579-021-00612-w

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Linking genotype to phenotype is particularly challenging for viruses because of their small size, sparse phenotypic data and interlinked viral, host and environmental factors. In this Review, DeLong and colleagues discuss traits of virions and virocells and phenotypic plasticity. Understanding how phenotypes emerge from genotypes is a foundational goal in biology. As challenging as this task is when considering cellular life, it is further complicated in the case of viruses. During replication, a virus as a discrete entity (the virion) disappears and manifests itself as a metabolic amalgam between the virus and the host (the virocell). Identifying traits that unambiguously constitute a virus's phenotype is straightforward for the virion, less so for the virocell. Here, we present a framework for categorizing virus phenotypes that encompasses both virion and virocell stages and considers functional and performance traits of viruses in the context of fitness. Such an integrated view of virus phenotype is necessary for comprehensive interpretation of viral genome sequences and will advance our understanding of viral evolution and ecology.

引用

页码：83 / 94

页数：12

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