The discovery of small molecule C5a antagonists

[21] Pharmacological characterization of antagonists of the C5a receptor [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1999, 128 (07) : 1461 - 1466

[22] A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug [J]. JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (11) : 4464 - 4471

[23] Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1999, 126 (03) : 551 - 554

[24] 2-SITE BINDING OF C5A BY ITS RECEPTOR - AN ALTERNATIVE BINDING PARADIGM FOR G-PROTEIN-COUPLED RECEPTORS [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (04) : 1214 - 1218

[25] Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134 (08) : 1778 - 1786

[26] Identification of a potent and orally active non-peptide C5a receptor antagonist [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (51) : 49403 - 49407

[27] β-amyloid fibrils activate the C1 complex of complement under physiological conditions:: Evidence for a binding site for Aβ on the C1q globular regions [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (11) : 6374 - 6381

[28] TAYLOR S, 2003, Patent No. 033528

[29] THURKAUF A, 2002, Patent No. 049992

[30] THURKAUF A, 2004, Patent No. 018460

[21] Pharmacological characterization of antagonists of the C5a receptor [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1999, 128 (07) : 1461 - 1466

[22] A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug [J]. JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (11) : 4464 - 4471

[23] Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1999, 126 (03) : 551 - 554

[24] 2-SITE BINDING OF C5A BY ITS RECEPTOR - AN ALTERNATIVE BINDING PARADIGM FOR G-PROTEIN-COUPLED RECEPTORS [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (04) : 1214 - 1218

[25] Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134 (08) : 1778 - 1786

[26] Identification of a potent and orally active non-peptide C5a receptor antagonist [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (51) : 49403 - 49407

[27] β-amyloid fibrils activate the C1 complex of complement under physiological conditions:: Evidence for a binding site for Aβ on the C1q globular regions [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (11) : 6374 - 6381

[28] TAYLOR S, 2003, Patent No. 033528

[29] THURKAUF A, 2002, Patent No. 049992

[30] THURKAUF A, 2004, Patent No. 018460