The discovery of small molecule C5a antagonists

被引：11
作者：
Hutchison, AJ [1 ]
Krause, JE [1 ]
机构：
[1] Neurogen Corp, Branford, CT 06405 USA
来源：
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 39 | 2004年 / 39卷
关键词：
D O I：
10.1016/S0065-7743(04)39011-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：139 / 147
页数：9
相关论文
共 35 条
  • [1] A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats
    Arumugam, TV
    Shiels, IA
    Strachan, AJ
    Abbenante, G
    Fairlie, DP
    Taylor, SM
    [J]. KIDNEY INTERNATIONAL, 2003, 63 (01) : 134 - 142
  • [2] Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine
    Arumugam, TV
    Shiels, IA
    Woodruff, TM
    Reid, RC
    Fairlie, DP
    Taylor, SM
    [J]. JOURNAL OF SURGICAL RESEARCH, 2002, 103 (02) : 260 - 267
  • [3] New non peptidic C5a receptor antagonists
    Astles, PC
    Brown, TJ
    Cox, P
    Halley, F
    Lockey, PM
    McCarthy, C
    McLay, IM
    Majid, TN
    Morley, AD
    Porter, B
    Ratcliffe, AJ
    Walsh, RJA
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (07) : 907 - 912
  • [4] A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization.
    deLaszlo, SE
    Allen, EE
    Li, B
    Ondeyka, D
    Rivero, R
    Malkowitz, L
    Molineaux, C
    Siciliano, SJ
    Springer, MS
    Greenlee, WJ
    Mantlo, N
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (02) : 213 - 218
  • [5] ARGININE-206 OF THE C5A RECEPTOR IS CRITICAL FOR LIGAND RECOGNITION AND RECEPTOR ACTIVATION BY C-TERMINAL HEXAPEPTIDE ANALOGS
    DEMARTINO, JA
    KONTEATIS, ZD
    SICILIANO, SJ
    VANRIPER, G
    UNDERWOOD, DJ
    FISCHER, PA
    SPRINGER, MS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (27) : 15966 - 15969
  • [6] Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a
    Finch, AM
    Wong, AK
    Paczkowski, NJ
    Wadi, SK
    Craik, DJ
    Fairlie, DP
    Taylor, SM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (11) : 1965 - 1974
  • [7] FLANAGAN KL, 1985, 210 ACS NAT M CHIC I
  • [8] C5A ANAPHYLATOXIN AND ITS 7 TRANSMEMBRANE-SEGMENT RECEPTOR
    GERARD, C
    GERARD, NP
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 : 775 - 808
  • [9] Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis
    Grant, EP
    Picarella, D
    Burwell, T
    Delaney, T
    Croci, A
    Avitahl, N
    Humbles, AA
    Gutierrez-Ramos, JC
    Briskin, M
    Gerard, C
    Coyle, AJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (11) : 1461 - 1471
  • [10] Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis
    Guo, RF
    Huber-Lang, M
    Wang, X
    Sarma, V
    Padgaonkar, VA
    Craig, RA
    Riedemann, NC
    McClintock, SD
    Hlaing, T
    Shi, MM
    Ward, PA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (10) : 1271 - 1280
1234