Fetal Growth Restriction and Asthma: Is the Damage Done?

被引：11
作者：
Wang, Kimberley C. W. [1 ,2 ]
James, Alan L. [3 ,4 ]
Noble, Peter B. [1 ]
机构：
[1] Univ Western Australia, Sch Human Sci, Crawley, WA, Australia
[2] Univ Western Australia, Telethon Kids Inst, Nedlands, WA, Australia
[3] Sir Charles Gairdner Hosp, West Australian Sleep Disorders Res Inst, Dept Pulm Physiol & Sleep Med, Nedlands, WA, Australia
[4] Univ Western Australia, Med Sch, Nedlands, WA, Australia
来源：
PHYSIOLOGY | 2021年 / 36卷 / 04期
基金：
英国医学研究理事会;
关键词：
airway remodeling; airway smooth muscle; asthma; inflammation; intrauterine growth restriction; AIRWAY SMOOTH-MUSCLE; ADULT LUNG-FUNCTION; LOW-BIRTH-WEIGHT; BRONCHIAL SEGMENTS; VENTILATION HETEROGENEITY; DEEP INSPIRATION; FLOW OBSTRUCTION; HEART-DISEASE; RESPONSIVENESS; CHILDREN;
D O I：
10.1152/physiol.00042.2020
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Trajectories of airway remodeling and functional impairment in asthma are consistent with the notion that airway pathology precedes or coincides with the onset of asthma symptoms and may be present at birth. An association between intrauterine growth restriction (IUGR) and asthma development has also been established, and there is value in understanding the underlying mechanism. This review considers airway pathophysiology as a consequence of IUGR that increases susceptibility to asthma.
引用
收藏
页码：256 / 266
页数：11
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