A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives

被引：10
|
作者：
Long, Binyu [1 ,2 ]
Tian, Binghua [1 ]
Tang, Qiang [1 ,2 ]
Hu, Xiangnan [1 ,2 ]
Han, Lei [1 ]
Wang, Zifan [1 ]
Wang, Chenyu [1 ]
Wu, Yue [1 ]
Yu, Yu [1 ]
Gan, Zongjie [1 ]
机构：
[1] Chongqing Med Univ, Dept Med Chem, Coll Pharm, Chongqing 400016, Peoples R China
[2] Chongqing Med Univ, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China
来源：
TETRAHEDRON | 2021年 / 96卷
基金：
中国国家自然科学基金;
关键词：
2-amino-1,3,4-thiadiazoles; KHSO4; Cyclodesulfurization; EFFICIENT SYNTHESIS; 1,3,4-OXADIAZOLE; DESIGN; BEARING; REAGENT; MILD;
D O I：
10.1016/j.tet.2021.132382
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles has been established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room temperature and produced corresponding products in moderate to good yields. This protocol also showed good functional group tolerance. (C) 2021 Elsevier Ltd. All rights reserved.
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页数：8
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